Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The key study was an activated sludge respiration inhibition test on of methyl benzoate (a member of the same chemical category, based on read-across), conducted in accordance with an established guideline and GLP.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 815 mg/L
Additional information
The microbial toxicity of the substance was determined from an activated sludge respiration inhibition test on methyl benzoate(a member of the same chemical category, based upon read-across); the EC50 was reported as 815 mg/L.
This information is from the substance, methyl benzoate, (CAS RN 93-58-3) as part of a category approach used for the assessment of several endpoints of isopropyl benzoate (CAS RN 939-48-0), the registered substance. The hypothesis for the category of Alkyl Benzoates is a common functional group (a benzoic acid ester) of similar carbon chain length. This small difference in carbon chain length and molecular weight between the ester groups of methyl benzoate and isopropyl benzoate is not anticipated to have a significant effect on toxicity or environmental behaviour. For each endpoint study based upon read-across, the category approach is substantiated by an evaluation provided in the Chemical Category Report Format (CCRF) attached to the endpoint study summary file. The CCRF provides the rationale so that the read-across information cited to fulfil the information requirements of the REACH Annexes VII-X may form the basis for classification and labelling decisions, hazard assessment and risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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