Registration Dossier
Registration Dossier
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EC number: 253-981-4 | CAS number: 38517-37-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 24, 2016 to July 21, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch no.: not specified
Appearance: solid - Key result
- Water solubility:
- 221 900 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 6.78
- Conclusions:
- Under the study conditions, the water solubility of the substance was determined to be 221900 mg/L at 20°C and pH 6.78.
- Executive summary:
A study was conducted to determine the water solubility of the substance according to OECD Guideline 105 and EU Method A.6. About 5 g of the test substance were weighed and added to 20 mL deionized water. The resulting solutions were stirred in a heated water bath at 30°C for 24, 48 and 72 h. After incubation, the suspensions were cooled down to 20°C and kept at this temperature for 24 h without stirring. Afterwards, the samples were centrifuged (4500 U/min) at 20°C for 30 min. The cloudy water phases were filtered, 0.5 mL of the clear phases were diluted to 25 mL methanol with 10% acetic acid and then analysed by liquid chromatography. Under the study conditions, the water solubility of the substance was determined to be 221900 mg/L at 20°C and pH 6.78 (Schwarzkopf, 2016).
Reference
Description of key information
The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Schwarzkopf, 2016).
Key value for chemical safety assessment
- Water solubility:
- 221 900 mg/L
- at the temperature of:
- 20 °C
Additional information
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