Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

other: Bibliographic source

Adequacy of study:

weight of evidence

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

publication

Title:

Effects of antimony on aquatic organisms (Larva and embryo of Oryzias latipes, Moina macrocopa, Simocephalus mixtus, and Pseudokirchneriella subcapitata)

Author:

Sun-Hwa Nam, Chang-Yong Yang, Youn-Joo An

Year:

2009

Bibliographic source:

Department of Environmental Science, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

Cas Number:

28300-74-5

Molecular formula:

C8H4K2O12Sb2 ∙ 3H2O

Details on test material:

Trihydrate salt.

Sampling and analysis

Analytical monitoring:

not specified

Details on sampling:

S. mixtus was collected from the farm pond in Namyangju city, Korea.

Test solutions

Vehicle:

no

Details on test solutions:

ATP>= 99.9% and used without further purification. Stock solution of APT was prepared in distilled water. Stock solution was diluted to obtain
suitable concentrations of APT in dechlorinated tap water, embryo rearing solution, moderately hard water (MHW) medium of USEPA
(2002), and algal medium for fish, fertilized eggs, planktonic crustacea, and green algae, respectively.

Test organisms

Test organisms (species):

other: Simocephalus mixtus

Study design

Test type:

not specified

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

24 h

Remarks on exposure duration:

the 48 h-LC50 value was not calculated in the present study. S. mixtus seems to be vulnerable to starvation, and exposure duration less than 48 h may be appropiate for the acute toxicity test.

Test conditions

Hardness:

moderately hard water (MHW)

Test temperature:

at 21 and 24 ºC

Details on test conditions:

Ten milliliters of MHW medium was placed in 35-mL flat-bottomed glass vial. Each test unit contained five neonates (less than 24 h), and test was done with three replicates. Toxicity endpoint selected for S. mixtus was heart beating under microscope because this species tends to stay at the surface of test unit and its movement is not active enough to measure the conventional immobilization.

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Key result

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

ca. 4.92 mg/L

Nominal / measured:

not specified

Conc. based on:

element

Remarks:

antimony

Basis for effect:

lack of heartbeat (embryo)

Details on results:

The 24-h LC50 value of antimony for S. mixtus was determined to be 4.92 mg/L.

Applicant's summary and conclusion

Conclusions:

The 24-h LC50 value of antimony for S. mixtus was determined to be 4.92 mg/ L.