Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

other: bibliographic source

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Toxicity of Industrial Metals

Author:

Browning, E.

Year:

1969

Bibliographic source:

Appleton-Century-Crofts

Reference 2

Reference Type:

publication

Title:

On the nitrogen metabolism in experimental subacute arsenic and antimony poisoning

Author:

Pribyl, E.

Year:

1947

Bibliographic source:

U.S. Public Health Service Public Health Reports, Supplement No. 195

Materials and methods

Principles of method if other than guideline:

Rabbits were used as experimental animals and in one group a subacute poisoning by sodium arsenite and in the other by antimony potassium tartrate was produced. The urines were collected from metabolism cages every 24 hours and preserved with toluene. At regular intervals blood was taken from the marginal ear vein.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

EC Number:

234-293-3

EC Name:

Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

Cas Number:

11071-15-1

Molecular formula:

C8H4O12Sb2.2K

IUPAC Name:

(2R,3R)-2,3-dihydroxy-butanedioic acid, antimony potassium salt

Test animals

Species:

other: rabbit

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: feed

Vehicle:

other: milk and glucose

Details on oral exposure:

The rabbits were fed on 75 cc. of milk and 50 gm. of glucose per kilo of weight of rabbit per day in two meals, one at IO a.m. and one at 10 p.m. When the animals were unable to take food they were fed by stomach tube.

Doses:

The dose of antimony potassium tartrate given per os in solution was 10 and 15 mg., respectively, per kilo of body weight, being administered in serveral increasing doses.

Control animals:

other: Four rabbits were poisoned by sodium arsenite

Results and discussion

Effect levels

Remarks on result:

not measured/tested

Mortality:

No mortality

Clinical signs:

other: There was a rise in non-protein nitrogen and urea nitrogen in blood and urine. Te urea nitrogen quotient was almost the same in urines of Rabbits II and III. In Rabbit I there was a fall and in Rabbit IV a marked derecrease. The ammonia nitrogen quotient

Gross pathology:

Rabbit I : Hemorrhages in stomach and small intestine. Liver atrophied, of slight yellow color in the margin of the lobes. Kidneys were without pathological changes macroscopically. Microscopical Examination.-Liver: Parenchymal cells in the intermediary zone of the lobules contained fat; those at the periphery were in a state of beginning fatty degeneration. Kidneys : Slight congestion of tubules and glomeruli.
Rabbit Il.-The same pathological changes in gastrointestinal tract as in Rabbit I. Liver slightly congested and atrophied. Kidneys showed hemorrhages in the cortex. Microscopical Examination.-Liver: Fatty degeneration of cells in the intermediary zone of lobules marked. The peripheral cells without fat.
Kidneys: The lumina of tubules obliterated with necrosed cells.
Rabbit III.-Hemorrhages in stomach and small intestine. Liver showed marked atrophy and yellow color. Kidneys showed hemorrhages in the cortex.
Microscopical Examination.-Liver: Parenchymal cells in a state of necrosis. Nuclei not much stained; fatty degeneration advanced. Kidneys: Congestion of glomeruli.
Rabbit IV.-Congestion with hemorrhages in stomach and small intestine. Liver showed slight atrophy, yellow color. Kidneys showed the periphery of the cortex lighter in color. Microscopical Examination.-Liver: Parenchymal cells in the intermediary zone of the lobules contained fat; those of the periphery contained none. Kidneys: Glomeruli showed slight congestion.

Applicant's summary and conclusion

Conclusions:

Experimental subacute poisoning in four rabbits has shown that there is an increase of non-protein nitrogenin blood after administration of tartar emetic. The rise of non-protein nitrogen and urea nitrogen in blood is associated with an increase of these constituents in the urine.