Registration Dossier
Registration Dossier
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EC number: 234-293-3 | CAS number: 11071-15-1
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Catalog of Teratogenic Agents
- Author:
- Shepard, T.H.
- Year:
- 1 986
- Bibliographic source:
- Baltimore : Johns Hopkins University Press
Materials and methods
- Principles of method if other than guideline:
- 2 mg/Kg of antimony potassium tartrate were given to 4 sheep during major portion of gestation.
Chicks were given to 0.10 mg on the 4th day of incubation. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer
- EC Number:
- 234-293-3
- EC Name:
- Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer
- Cas Number:
- 11071-15-1
- Molecular formula:
- C8H4O12Sb2.2K
- IUPAC Name:
- (2R,3R)-2,3-dihydroxy-butanedioic acid, antimony potassium salt
Constituent 1
Test animals
- Species:
- other: sheep and chick
Results and discussion
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 2.7 mg/kg bw/day (actual dose received)
Applicant's summary and conclusion
- Conclusions:
- No fetal changes were found in sheep. No defects were observed in chicks.
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