Dipotassium bis[μ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics, other

Type of information:

other:

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Toxicological Profile for Antimony and Compounds

Author:

Agency for Toxic Substances and Disease Registry

Year:

2017

Bibliographic source:

ATSDR

Reference 2

Reference Type:

publication

Title:

Scientific Basis for Swedish Occupational Standards XXI

Author:

Group for Occupational Standards
Ed. Johan Montelius

Year:

2000

Bibliographic source:

National Institute for Working Life

Reference 3

Reference Type:

review article or handbook

Title:

ANTIMONY POTASSIUM TARTRATE

Author:

WN Harrison; SM Bradberry; JA Vale

Year:

2011

Bibliographic source:

UKPID MONOGRAPH

Materials and methods

Objective of study:

toxicokinetics

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Antimony

EC Number:

231-146-5

EC Name:

Antimony

Cas Number:

7440-36-0

Molecular formula:

Sb

Radiolabelling:

yes

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

Antimony compounds may be absorbed by inhalation and ingestion.

Details on distribution in tissues:

Absorbed trivalent antimony readily enters red blood cells and accumulates primarily in the spleen, liver and bone. No sex-or age-related differences in antimony concentrations were found.
In vitro experiments with human blood have shown that Antimony accumulated in the red blood cells of rats repeatedly exposed to antimony potassium tartrate via drinking water; concentrations of antimony measured in organs were much lower (spleen, liver >kidneys >brain, fat).
Lauwers et al (1990) estimated that the total body antimony pool in a patient who died following accidental antimony potassium tartrate ingestion was only five per cent of the ingested dose with high antimony concentrations in the liver, gall bladder and gastrointestinal mucosa. This is consistent with antimony undergoing enterohepatic circulation.
In two studies with rodents, the portion of the total body burden of antimony in the lungs was calculated with the help of isotope-labeled antimony. It was found that <1% was in the lungs 2 hours after inhalation exposure to an aerosol of trivalent or pentavalent antimony tartrate

Details on excretion:

Antimony compounds are eliminated mainly in the urine, with small amounts appearing in faeces via bile after conjugation with glutathione.

Metabolite characterisation studies

Metabolites identified:

no

Applicant's summary and conclusion

Executive summary:

Antimony and compounds, considered suitable for read-across to Potassium Sodium Tartrate is absorbed by inhalation and ingestion and accumulates in red blood cells, the spleen, liver and bones. The main excretion pathway for antimony is reported to be via the kidneys.