Registration Dossier
Registration Dossier
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EC number: 205-528-7 | CAS number: 142-22-3
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: clinical observations and experimental results
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no information about GLP compliance of the published study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
- Study type:
- human medical data
- Remarks:
- obtained from clinical and experimental studies carried out in the employees
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- EC Number:
- 205-528-7
- EC Name:
- Diallyl 2,2'-oxydiethyl dicarbonate
- Cas Number:
- 142-22-3
- Molecular formula:
- C12H18O7
- IUPAC Name:
- 3-({[2-(2-{[(prop-2-en-1-yloxy)carbonyl]oxy}ethoxy)ethoxy]carbonyl}oxy)prop-1-ene
- Details on test material:
- Gas chromatographic and HPLC analysis of the DAGC revealed minor contamination with acrolein (18 ppm) and allyl alcohol (28 ppm).
Constituent 1
Method
- Type of population:
- other: workers
- Ethical approval:
- not specified
- Details on study design:
- Patch Test
Results and discussion
- Results:
- Of the 7 operatives patch tested, 1 developed an allergic reaction to nickel sulphate 5% pet. and gave a previous history of nickel sensitivity. Patch tests were otherwise negative apart from minor irritant reactions to the diallyl glycol carbonate (DAGC) plus 3% isopropyl percarbonate (IPP) mixture at 0.1%. Similar irritant reactions to this mixture were seen in 5 control subjects.
Applicant's summary and conclusion
- Conclusions:
- In all patients, the eruptions all appear to have been irritant rather than allergic in origin.
- Executive summary:
"We report an outbreak of irritant contact dermatitis from diallylglycol carbonate monomer among factory employees making optical plastic lenses. Symptoms lessened after simple preventive methods were introduced. Further upgrading of production methods lessened symptoms still further."
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