Diphosphoric acid, compound with 1,3,5-triazine-2,4,6-triamine

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 July 2010 to 20 January 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study conducted in accordance with an internationally recognised method

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Sieving and image analysis (microscopy)

Type of distribution:

mass based distribution

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Particle size	% Mass
(µm)	Test 1	Test 2	Test 3		Test 4	Test 5	Test 6	Mean
105 - 130 60.0 - 105 30.0 - 60.0 10.4 - 30.0 0.5 - 10.4	39.3 27.5 18.6 13.9 0.7	25.0 36.8 23.8 13.5 0.9	31.1 44.8 15.9 7.6 0.5	19.7 46.5 21.0 11.9 0.8		18.2 50.4 22.7 7.8 0.9	8.4 56.5 26.2 8.5 0.4	23.6 43.8 21.4 10.5 0.7

Conclusions:

The results indicated that 0.7% w/w of MPP was smaller than 10 µm.

Description of key information

The results indicate that 0.7% w/w of MPP was smaller than 10 µm.

Additional information

The particle size distribution was determined by a combination of sieving and image analysis with combination of the results to produce a mass distribution. The results indicate that only a very small proportion of MPP is of respirable size (0.7% <10µm) and it can be expected not to present an inhalation hazard.