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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 December 2003 and 11 March 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study conducted in accordance with an internationally recognised method
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
0.375 g/L
Temp.:
20 °C
pH:
3.6
Remarks on result:
other: Organic component as determined by HPLC
Details on results:
The water solubility of 0.376 is obtained by summation of the organic component concentration obtained by HPLC analysis (0.225 g/l) and the inorganic component concentration determined by ion chromatography (0.150 g/l).

Organic component analysed at 24, 48 and 72 hrs = 0.227, 0.225 and 0.224 g/l

Inorganic component analysed at 24, 48 and 72 hrs - 0.151, 0.148 and 0.152 g/l

Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The water solubility of MPP has been determined as 0.375 g/l at 20°C.

Description of key information

The water solubility of MPP has been determined as 0.375 g/l at 20°C.

Key value for chemical safety assessment

Water solubility:
0.375 g/L
at the temperature of:
20 °C

Additional information

The water solubility of 0.375 g/l is obtained by summation of the organic component concentration obtained by HPLC analysis (0.225 g/l) and the inorganic component concentration determined by ion chromatography (0.150 g/l).