Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-424-2 | CAS number: 578-54-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
No genetic toxicity for 2-ethylaniline (Ames test and unscheduled DNA synthesis in rodent hepatocytes)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In vitro studies
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to Thompson et all, Environ Mutagen, 5(6):803-811, 1983 2-ethylanylnie resulted negative in Salmonella typhimuriumstrains TA98, TA100, TA1535, TA1537, TA1538, G46, C3076, and D3052 and in Escherichia colistrains WP2 and WP2uvrA- with or without S9.
Always in Chemical Information Profile for Alkylaniline NTP 2009 with reference to Thompson et all, Environ Mutagen, 5(6):803-811, 1983 it is reported that 2-ethylaniline did not induce unscheduled DNA synthesis in rodent hepatocytes
In vivo studies
No data available
Conclusion
Based on above results, there is no reason of concern regarding genetic toxicity of 2-ethylaniline.
Justification for classification or non-classification
As reported in Chemical Information Profile for Alkylaniline NTP 2009 2 -ethylaniline was negative in Ames test and in unscheduled DNA synthesis in rodent hepatocytes.
No classification is proposed for genetic toxicity of 2-ethylaniline according to the CLP Regulation (EC n. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
