Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

2-ethylaniline has got a not negligible acute toxicity: oral LD50 rat = 1260 mg/kg/bw, dermal LD50 rabbit = 840 mg/kg/bw and inhalation LD0 rat = 1.07 mg/l (220 ppm)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 260 mg/kg bw
Quality of whole database:
Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
840 mg/kg bw
Quality of whole database:
Data from reliable source (Chemical Information Profile for Alkylaniline NTP 2009)

Additional information

Oral exposure:

As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to database ChemIDplus and to Jacobsen, Toxicology and Applied Pharmacology. Vol. 22, Pg. 153, 1972 LD50 oral rat for 2-ethylaniline is 1260 mg/kg/bw. At this concentration somnolence (general depressed activity); cyanosis in the lungs, thorax, or respiratory tract; blood changes in spleen were observed in rats. Based on this data and according to the CLP Regulation (EC n. 1272/2008) the classification H302 (acute oral toxicity cat.4) is proposed for 2-ethylaniline.

 

Inhalation exposure:

As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference toU.S. EPA (Environmental Protection Agency). 2006. High Production Volume (HPV) Challenge Program. Robust Summaries & Test Plans: Ring Substituted Anilines Category. Cover letter (dated May 4, 2006), test plan, and robust summaries submitted to the U.S. EPA Chemical Right-to-Know Program by Dr. Len Sweet of Albemarle Corporation, Baton Rouge, LA, pp.121 LD0 inhalation rat for 2-ethylaniline is 1.07 mg/l (220 ppm). No indication regarding the convertion beetween these two values is reported. This data is conclusive but not sufficient for classification.

 

Dermal  exposure:

As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to U.S. EPA (Environmental Protection Agency). 2006. High Production Volume (HPV) Challenge Program. Robust Summaries & Test Plans: Ring Substituted Anilines Category. Cover letter (dated May 4, 2006), test plan, and robust summaries submitted to the U.S. EPA Chemical Right-to-Know Program by Dr. Len Sweet of Albemarle Corporation, Baton Rouge, LA, pp.121 LD50 dermal rabbit for 2-ethylaniline is 840 mg/kg/bw. Based on this data and according to the CLP Regulation (EC n. 1272/2008) the classification H311 (acute dermal toxicity cat.3) is proposed for 2-ethylaniline.

In this summary are reported data owner studies published by NTP. They have been used for precautionary purposes and for the benefit of the human health .Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.

Justification for classification or non-classification

2-ethylaniline has got a not negligible acute toxicity: oral LD50 rat = 1260 mg/kg/bw, dermal LD50 rabbit = 840 mg/kg/bw and inhalator LD0 rat = 1.07 mg/l (220 ppm). Based on these data and according to the CLP Regulation (EC n. 1272/2008) the classification H302 (acute oral toxicity cat.4) and H311 (acute dermal toxicity cat.3) is proposed for 2-ethylaniline.