Registration Dossier
Registration Dossier
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EC number: 209-424-2 | CAS number: 578-54-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to Liu et all., Chem Res Toxicol, 20:1300-1308,2007 2-ethylaniline is N-Acetylated by N-acetyltransferase 2 but not by N-acetyltransferase 1.
In Chemical Information Profile for Alkylaniline NTP 2009 is reported also a general methabolism mechanism in rats for Arylamines: Arylamines are metabolized by ring oxidation,N-glucuronidation,N-acetylation, and N-oxidation; in the liver (of mammals) they are metabolized toN-hydroxyarylamines by monooxygenases (usually cytochrome P450) before binding to hemoglobin. Moreover the hemoglobin binding index in female rats is lower for 2-ethylaniline (5.1) if compared with aniline (22) or 3- and 4-ethylniline (12.7 and 5.8 respectively) (4) (Sabbioni,Environ Health Perspect, 102(Suppl. 6):61-67,1994).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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