Registration Dossier
Registration Dossier
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EC number: 209-424-2 | CAS number: 578-54-1
Endpoint summary
Administrative data
Description of key information
2-ethylaniline is not classified as a skin irritant but it is probably eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
As reported in Chemical Information Profile for Alkylaniline NTP 2009 with reference to U.S. EPA (Environmental Protection Agency). 2006. High Production Volume (HPV) Challenge Program. Robust Summaries & Test Plans: Ring Substituted Anilines Category. Cover letter (dated May 4, 2006), test plan, and robust summaries submitted to the U.S. EPA Chemical Right-to-Know Program by Dr. Len Sweet of Albemarle Corporation, Baton Rouge, LA, pp.121 2-ethylaniline was not classified as a skin irritant in rabbits but was a mild eye irritant. No details regarding these studies are reported in Chemical Information Profile for Alkylaniline NTP 2009.
In this summary are reported data owner studies published by NTP. They have been used for precautionary purposes and for the benefit of the human health .Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Based on precautionary principle and according to the CLP Regulation (EC n. 1272/2008) the classification H319 (Eye Irrit. cat.2) is proposed for 2-ethylaniline.
Justification for classification or non-classification
As reported in Chemical Information Profile for Alkylaniline NTP 2009 2-ethylaniline was not classified as a skin irritant in rabbits but was a mild eye irritant.
Based on precautionary principle and according to the CLP Regulation (EC n. 1272/2008) the classification H319 (Eye Irrit. cat.2) is proposed for 2-ethylaniline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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