Registration Dossier
Registration Dossier
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EC number: 205-778-7 | CAS number: 150-90-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute toxicity - test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS database
- Reference Type:
- secondary source
- Title:
- IUCLID DATASET
- Author:
- EUROPEAN COMMISSION – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- IUCLID DATASET- EUROPEAN COMMISSION – European Chemicals Bureau, 18–FEB–2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium chloroacetate
- EC Number:
- 223-498-3
- EC Name:
- Sodium chloroacetate
- Cas Number:
- 3926-62-3
- Molecular formula:
- C2H3ClO2.Na
- IUPAC Name:
- Sodium chloroacetate
- Details on test material:
- - IUPAC Name: Sodium chloroacetate
- InChI: 1S/C2H3ClO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
- Smiles: [O-]C(CCl)=O.[Na+]
- Molecular formula :C2H2ClNaO2
- Molecular weight :116.4788 g/mol
- Substance type:Organic
- Physical state:Solid crystals or powder white
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed in animals at 2000 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute dermal LD50 value was considered to be >2000 mg/kg bw, when rats were treated with the given test chemical by dermal application.
- Executive summary:
Acute dermal toxicity study of the given test chemical was conducted as per OECD Guideline 402 "Acute dermal Toxicity” in rats at the dose concentration of 2000 mg/kg bw.
Animals were observed for mortality. No mortality was observed in animals at 2000 mg/kg bw.
Therefore, the LD50 value was considered to be >2000 mg/kg bw, when rats were treated with the given test chemical by dermal application.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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