Disodium succinate

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

pour density and tapped density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23-01-2018 – 23-01-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of Test item was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

pycnometer method

Specific details on test material used for the study:

- Name of test material (as cited in study report): Disodium succinate
- Molecular formula (if other than submission substance): C4-H6-O4.2Na
- Molecular weight (if other than submission substance): 162.052
- Smiles notation (if other than submission substance): C(CCC(=O)[O-])(=O)[O-].[Na+].[Na+]
- InChl (if other than submission substance): 1S/C4H6O4.2Na/c5-3(6)1-2-4(7)8;;/h1-2H2,(H,5,6)(H,7,8);;/q;2*+1/p-2
- Substance type: Organic
- Physical state: Solid

Key result

Type:

pour density

Density:

0.556 g/cm³

Temp.:

26 °C

Remarks on result:

other: at 974.4 hPa pressure.

Key result

Type:

tap density

Density:

0.8 g/cm³

Temp.:

26 °C

Remarks on result:

other: at 974.4 hPa pressure.

TEST ITEM DESCRIPTION AND RESULTS

 FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1st Reading	2ndReading
Method	Test methods: Pour density and tapped density of powders” recommended inThe International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density: It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density: It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	26.5°C	26.6°C
Atmospheric pressure (in hPa)	-	975.9	972.9
Weight of test item(m)		20.008	20.006
Volume of measuring cylinder; readability in g		50ml;1 ml	50 ml;1 ml
Volume of test item without tapping (V)		35	37
Volume of test item after tapping ( V1)	After 10 tapping	29	28
	After 50 tapping	25	25
	After 100 tapping	25	25
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 Tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

CALCULATIONS:

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	=m V	0.5716	0.5407	0.5561
Tap density of test Item (g/cm³)	=m V1	0.8003	0.8002	0.8002

Conclusions:

The mean pour density and tapped density of test chemical was determine to be 0.5561 g/cm³ and 0.8002 g/cm³ at 26°C and 974.4 hPa.

Executive summary:

The density of test item was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was found to be 0.5561 g/cm³ and 0.8002 g/cm³ at 26°C and 974.4 hPa..

Description of key information

The mean pour density and tapped density of test chemical was determine to be 0.5561 g/cm³ and 0.8002 g/cm³ at 26°C and 974.4 hPa.

Additional information

The density of test item was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density apparatus.The mean pour density and tapped density of test item was found to be 0.5561 g/cm³ and 0.8002 g/cm³ at 26°C and 974.4 hPa.

From reliable sources density of test chemical is determine to be 1.89 g/cm3 at temperature 25 Deg C.