Disodium succinate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22-01-2018 – 25-01-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

The water solubility determination of test item was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101.

GLP compliance:

no

Type of method:

other: spectrophotometric analytical method

Specific details on test material used for the study:

- Name of test material (as cited in study report): Succinic acid, disodium salt
- Molecular formula (if other than submission substance): C4-H6-O4.2Na
- Molecular weight (if other than submission substance): 162.052
- Smiles notation (if other than submission substance): C(CCC(=O)[O-])(=O)[O-].[Na+].[Na+]
- InChl (if other than submission substance): 1S/C4H6O4.2Na/c5-3(6)1-2-4(7)8;;/h1-2H2,(H,5,6)(H,7,8);;/q;2*+1/p-2
- Substance type: Organic
- Physical state: Solid

Key result

Water solubility:

455 760 mg/L

Conc. based on:

test mat.

Temp.:

25 °C

Remarks on result:

other: no other details mentioned

WATER SOLUBILITY: PRELIMINARY TEST

0.1g of test item was taken in 100 ml beaker. DI water was added in increasing amount in sequence of 0.1 ml, 0.5 ml, 1.0 ml, 2.0 ml, 10.0 ml and 100.0 ml with intermediate stirring.

For highly soluble substances: Preliminary water solubility of test item was found 0.1g in 1 ml DI water. Five times the concentration recorded from preliminary solubility was used for confirmatory study.

WATER SOLUBILITY: CONFIRMATORY TEST

Five times the concentration recorded from preliminary solubility = 100000 mg/L × 5 = 500000 mg/L was used for confirmatory study. Two separate solution of 10 g in 20 ml DI water were prepared and kept for stirring for 48 hrs and 72 hrs. After the completion of stirring period the absorbance for all the two solution were recorded and concentration was detected on the basis of standard curve. Table 2 refers to the same.

Sample stirring	Concentration obtained on the basis of standard curve	Dilution factor	Solubility value obtained (mg/L)
24 hour	-	-	-
48 hour	121.22 mg/L	4000	484880 mg/L
72 hour	106.66 mg/L	4000	426640 mg/L

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=(484880+426640)/2

=455760 mg/L

Conclusions:

The water solubility for the test item was determine to be 455760 mg/L at 25°C.
From this solubility value it is concluded that test chemical is very soluble in water.

Executive summary:

The water solubility determination of test item was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determine to be 455760 mg/L at 25°C.

From this solubility value it is concluded that test chemical is very soluble in water.

Description of key information

The water solubility determination of test item was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determine to be 455760 mg/L at 25°C.

From this solubility value it is concluded that test chemical is very soluble in water.

Key value for chemical safety assessment

Water solubility:

455 760 mg/L

at the temperature of:

25 °C

Additional information

The water solubility determination of test item was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of test chemical in water was determine to be 455760 mg/L at 25°C.

From this solubility value it is concluded that test chemical is very soluble in water.

Other supporting study from authoritative database and handbook also supported the selected key study and exhibited the water solubility of test chemical as 350000 mg/L at 25°C, 200000 mg/l and greater than 100000 mg/L at 25°C respectively.

Based on these obtained values the given chemical is considered to be very soluble in water.