Registration Dossier
Registration Dossier
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EC number: 202-876-1 | CAS number: 100-66-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Several publications dealt with absorption, metabolism and glucuronidation are available. In most of these publications several food additives were examined.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 80
Additional information
Absorption: Bray et al.,1952 publication showed in a metabolism study performed in rabbits after oral administration (gavage) that anisole (0.5 g/kg) was mainly absorbed after oral route exposure. 80% of the administered dose were absorbed 24 hours after exposure.
In Fritsch et al., 1974 study in which an in situ perfusion in rats was used to study gastro-intestinal absorption, anisole was largely absorbed from the digestive tract by a mechanism of passive diffusion. 64.06 % of the dose were absorbed 120 minutes after perfusion (2 mg/L) by the gastric tract and 76.70% of the administered dose by the intestinal tract in the same conditions.
Distribution: No specific study on anisole distribution is available. However, based on the studies describing anisole absorption and metabolism, it has been showed that anisole is distributed via blood and the substance has been found in olfactory mucosa, olfactory bulb and liver.
Metabolism: In the study describing metabolism (Bray et al., 1952), the only metabolites observed in rabbit after oral exposure (gavage) are phenols excreted either free or as O-conjugates for approximately 80% of the administered dose. The main metabolite of anisole identified was p-methoxyphenol. Anisole metabolism involves the formation of a center for conjugation by hydroxylation, with conjugation of the resultant phenolic ethers with glucuronic and sulphuric acids.
In the last publication, the glucuronidation of a series of odorant molecules by homogenates prepared either with rat olfactory mucosa, olfactory bulb or brain was studied. For anisole the most activity was demonstrated in the olfactory mucosa, while the activity was very low in the olfatory bulb and not detected in the brain.
Excretion: In the studies describing the metabolism in the caecal flora of the rat (Fritsch et al;,1975a), and the absorption in the digestive tract (Fritsch et al.,1975b), it was demonstrated that anisole was completely absorbed and excreted. Anisole via metabolites is mainly excreted in urine and excretion by respiratory tract was not detected in rabbit after oral exposure.
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