Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-743-1 | CAS number: 72624-02-3
Endpoint summary
Administrative data
Description of key information
Additional information
In a study performed to a similar procedure to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test), Atlantic cod were exposed to 4-hepthylphenol at a concentration of 15.5 nmol/L (as 4-[14C]heptylphenol) under flow-through conditions with a 192 hour exposure period and a 192 hour elimination period.
The steady state BCF was 555 and the kinetic BCF was 578. Rate constants for uptake and elimination were 29.94 and 0.052/h respectively.
Elimination of 4-heptylphenol occurred rapidly following first order kinetics with an estimated biological half life of 13 hours. Substantial radioactivity was detected in seawater during the initial part of the elimination period but no radioactivity was detected in water after more than 96 hr recovery in clean seawater.
No radioactivity was detected in tissues of cod at the end of the elimination period, indicating a lack of retention in specific tissues. Radioactivity in autoradiograms extracted with nonpolar and polar solvents was not observed, giving additional support to the conclusion that 4-heptylphenol and metabolites do not bind to specific macromolecules or tissue structures in cod.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
