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EC number: 204-783-1 | CAS number: 126-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Sulfolane was not irritating to rabbit skin when applied under occlusive conditions for 6 hr/day on three consecutive days. When instilled into rabbit eyes, sulfolane produced mild conjunctivitis which cleared within a few hours.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Brown et al. (1966)
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tunstall Laboratory Breeding Unit - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 1 ml
- Duration of treatment / exposure:
- 6 hours, once per day for three applications
- Observation period:
- 7 days after first application
- Number of animals:
- 4 males and 4 females
- Details on study design:
- TEST SITE
Two 2 cm x 2 cm patches with 1 ml of test material were applied to the backs of rabbits and covered with a sheet of thin polythene. These were then bandaged into position by means of a 5 cm open-weave bandage.
REMOVAL OF TEST SUBSTANCE
- Not reported.
SCORING SYSTEM: According to Brown et al. (1966). - Irritation parameter:
- erythema score
- Basis:
- other: total for all 8 animals
- Remarks:
- Score according to Brown et al. (1966)
- Time point:
- other: final observations were made at 7 days
- Score:
- < 10
- Max. score:
- 32
- Remarks on result:
- other: Non-irritating
- Remarks:
- Erythema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
- Irritation parameter:
- edema score
- Basis:
- other: total for all 8 animals
- Remarks:
- Score according to Brown et al. (1966)
- Time point:
- other: final observations were made at 7 days
- Score:
- 0
- Max. score:
- 32
- Remarks on result:
- other: not irritating
- Remarks:
- Edema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
- Irritant / corrosive response data:
- No information is available.
- Other effects:
- No information is available.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sulfolane is a non-irritant to rabbit skin.
- Executive summary:
Sulfolane is a non-irritant to rabbit skin when applied under occlusive conditions for 6 hours a day on three consecutive days.
Reference
There was no sign of skin irritation in any of the rabbits. The use of sulphan blue showed the skin to be unchanged, and histopathological examination of skins taken from the rabbits post mortem revealed no evidence of skin damage.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: United States Federal Register: September 17, 1964: FR 13009 “Hazardous Substances”
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Tunstall Laboratory Breeding Unit - Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.2 ml
- Duration of treatment / exposure:
- Single instillation of test substance, according to the method described in United States Federal Register: September 17, 1964: FR 13009 “Hazardous Substances”.
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- Six rabbits, according to the method described in United States Federal Register: September 17, 1964: FR 13009 “Hazardous Substances”
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
Not reported, removal not indicated according to the method described in United States Federal Register: September 17, 1964: FR 13009 “Hazardous Substances”.
SCORING SYSTEM: U.S. Department of Health, Education and Welfare (Food and Drug Administration) - Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within:
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Remarks:
- All effects had resolved within a few hours, so it is considered by the reviewer that the score according to Draize would be 0 for each animal.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible within: a few hours
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: expert judgment, reported as a very mlld irritant
- Conclusions:
- Sulfolane was considered as mildly irritating to the eyes of rabbits, based on mild conjuctivitis which cleared within a few hours.
- Executive summary:
Sulfolane is a mild eye irritant to rabbits. When 0.2 ml sulfolane was instilled into the right eyes of rabbits, there was only mild conjunctivitis which cleared within a few hours.
Reference
Sulfolane produced only mild conjunctivitis which cleared within a few hours.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin Irritation
Brown et al.(1966) reported that sulfolane was a non-irritant to rabbit skin when applied under occlusive conditions for 6 hours per day on three consecutive days. There was no sign of skin irritation in any of the rabbits. The use of sulphan blue also showed the skin to be unchanged, and histopathological examination of skins taken from the rabbits post mortem revealed no evidence of skin damage.
Eye Irritation
Brown et al. (1966) reported that sulfolane was a mild eye irritant to rabbits. When 0.2 ml sulfolane was instilled into the right eyes of rabbits, there was only mild conjunctivitis which cleared within a few hours.
Justification for classification or non-classification
Skin Irritation
Classification proposal regarding skin irritation: GHS/CLP: None.
Eye Irritation
Classification proposal regarding eye irritation: GHS/CLP: None.
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