Tetrahydrothiophene 1,1-dioxide

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1966

Reference 2

Reference Type:

publication

Title:

Experimental Studies on Skin Hazard with 'Versatic' 9-11 Acid and its Monoglycidyl and Vinyl Esters.

Author:

Hunter, C. G., Brown, V. K., Ferrigan, L. W.

Year:

1966

Bibliographic source:

Occupational and Environmental Medicine, 23(2), 137-141.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Brown et al. (1966)

Principles of method if other than guideline:

No further information available.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydrothiophene 1,1-dioxide

EC Number:

204-783-1

EC Name:

Tetrahydrothiophene 1,1-dioxide

Cas Number:

126-33-0

Molecular formula:

C4H8O2S

IUPAC Name:

1λ⁶-thiolane-1,1-dione

Constituent 2

Reference substance name:

Sulfolane

IUPAC Name:

Sulfolane

Details on test material:

- Name of test material (as cited in study report): Sulfolane

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Tunstall Laboratory Breeding Unit

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

1 ml

Duration of treatment / exposure:

6 hours, once per day for three applications

Observation period:

7 days after first application

Number of animals:

4 males and 4 females

Details on study design:

TEST SITE
Two 2 cm x 2 cm patches with 1 ml of test material were applied to the backs of rabbits and covered with a sheet of thin polythene. These were then bandaged into position by means of a 5 cm open-weave bandage.

REMOVAL OF TEST SUBSTANCE
- Not reported.

SCORING SYSTEM: According to Brown et al. (1966).

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

other: total for all 8 animals

Remarks:

Score according to Brown et al. (1966)

Time point:

other: final observations were made at 7 days

Score:

< 10

Max. score:

32

Remarks on result:

other: Non-irritating

Remarks:

Erythema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8

Results 2

Irritation parameter:

edema score

Basis:

other: total for all 8 animals

Remarks:

Score according to Brown et al. (1966)

Time point:

other: final observations were made at 7 days

Score:

0

Max. score:

32

Remarks on result:

other: not irritating

Remarks:

Edema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8

Irritant / corrosive response data:

No information is available.

Other effects:

No information is available.

Any other information on results incl. tables

There was no sign of skin irritation in any of the rabbits. The use of sulphan blue showed the skin to be unchanged, and histopathological examination of skins taken from the rabbits post mortem revealed no evidence of skin damage.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Sulfolane is a non-irritant to rabbit skin.

Executive summary:

Sulfolane is a non-irritant to rabbit skin when applied under occlusive conditions for 6 hours a day on three consecutive days.