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Registration Dossier
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EC number: 204-783-1 | CAS number: 126-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 966
- Reference Type:
- publication
- Title:
- Experimental Studies on Skin Hazard with 'Versatic' 9-11 Acid and its Monoglycidyl and Vinyl Esters.
- Author:
- Hunter, C. G., Brown, V. K., Ferrigan, L. W.
- Year:
- 1 966
- Bibliographic source:
- Occupational and Environmental Medicine, 23(2), 137-141.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Brown et al. (1966)
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydrothiophene 1,1-dioxide
- EC Number:
- 204-783-1
- EC Name:
- Tetrahydrothiophene 1,1-dioxide
- Cas Number:
- 126-33-0
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- 1λ⁶-thiolane-1,1-dione
- Reference substance name:
- Sulfolane
- IUPAC Name:
- Sulfolane
- Details on test material:
- - Name of test material (as cited in study report): Sulfolane
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tunstall Laboratory Breeding Unit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 1 ml
- Duration of treatment / exposure:
- 6 hours, once per day for three applications
- Observation period:
- 7 days after first application
- Number of animals:
- 4 males and 4 females
- Details on study design:
- TEST SITE
Two 2 cm x 2 cm patches with 1 ml of test material were applied to the backs of rabbits and covered with a sheet of thin polythene. These were then bandaged into position by means of a 5 cm open-weave bandage.
REMOVAL OF TEST SUBSTANCE
- Not reported.
SCORING SYSTEM: According to Brown et al. (1966).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: total for all 8 animals
- Remarks:
- Score according to Brown et al. (1966)
- Time point:
- other: final observations were made at 7 days
- Score:
- < 10
- Max. score:
- 32
- Remarks on result:
- other: Non-irritating
- Remarks:
- Erythema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
- Irritation parameter:
- edema score
- Basis:
- other: total for all 8 animals
- Remarks:
- Score according to Brown et al. (1966)
- Time point:
- other: final observations were made at 7 days
- Score:
- 0
- Max. score:
- 32
- Remarks on result:
- other: not irritating
- Remarks:
- Edema was scored on a scale of 0-4. The maximum score for all animals is therefore 4*8
- Irritant / corrosive response data:
- No information is available.
- Other effects:
- No information is available.
Any other information on results incl. tables
There was no sign of skin irritation in any of the rabbits. The use of sulphan blue showed the skin to be unchanged, and histopathological examination of skins taken from the rabbits post mortem revealed no evidence of skin damage.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sulfolane is a non-irritant to rabbit skin.
- Executive summary:
Sulfolane is a non-irritant to rabbit skin when applied under occlusive conditions for 6 hours a day on three consecutive days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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