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EC number: 204-783-1 | CAS number: 126-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Principles of method if other than guideline:
- Directive 84/449/EEC. No further information available.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrahydrothiophene 1,1-dioxide
- EC Number:
- 204-783-1
- EC Name:
- Tetrahydrothiophene 1,1-dioxide
- Cas Number:
- 126-33-0
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- 1λ⁶-thiolane-1,1-dione
- Reference substance name:
- Sulfolane
- IUPAC Name:
- Sulfolane
- Details on test material:
- - Name of test material (as cited in study report): Sulfolane
- Physical state: Liquid, clear pale yellow
- Analytical purity: 97.4%
- Impurities: 2.6% water
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD.BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River U.K., Ltd.
- Age at study initiation: At least 7-8 weeks
- Weight at study initiation: mean Not reported
- Fasting period before study: Overnight
- Housing: 1-3 rats in stainless steel wire-mesh cages
- Diet: LAD 1, Special Diets Services, Ltd. ad libitum, except for pre-dose fast
- Water: Tap water ad libitum
- Acclimation period: at least seven days
ENVIRONMENTAL CONDITIONS
- Temperature: 19 – 23°C
- Humidity: 30 – 70%
- Air changes (per hr): Not reported
- Photoperiod: 12 hrs dark / 12hrs light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Test Site
- Type of wrap if used: a gauze dressing (approx. 6 x 8 cm) covered with waterproof adhesive tape.
Removal of Test Substance
- Washing (if done): with warm dilute detergent solution
- Time after start of exposure: 24 hours
Test Material
- Amount(s) applied (volume or weight with unit): 1.59 mL/kg
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations made at least six times on the day of dosing and twice daily thereafter for the remainder of the study. Body weights were measured prior to dosing, and thereafter on Day 1, 8 and 15.
- Necropsy of survivors performed: yes - Statistics:
- Not needed
Results and discussion
- Preliminary study:
- No information is available.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths.
- Clinical signs:
- other: The majority of rats showed staining (yellow) of the anogenital fur and one rat showed an unkempt appearance on Day 2 only. Erythema or discoloration (yellow) of the sites of application of the test material were common after removal of the dressings on D
- Gross pathology:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal rat LD50 of sulfolane was greater than 2000 mg/kg. No deaths were observed.
- Executive summary:
Undiluted sulfolane at a dose of 2000 mg/kg was applied to the skin of male and female Sprague-Dawley rats for 24 hours by an occlusive patch. There were no deaths. The acute dermal LD50 of sulfolane in rats is greater than 2000 mg/kg.
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