Registration Dossier
Registration Dossier
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EC number: 237-335-9 | CAS number: 13752-51-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to techniques specified in national regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations for the Enforcement of the Federal Hazardous Substances Act (Revised, Federal Register, Sept 17, 1964)
- Deviations:
- no
- Principles of method if other than guideline:
- Skin irritation was assessed as a part of the dermal toxicity study referenced above in 7.2.3
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
- Details on test material:
- - Name of test material (as cited in study report): 3030x18
- Physical state: sparkly white powder
- Other: Received at testing laboratory on Sept 3, 1971
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: abraded and unabraded
- Vehicle:
- physiological saline
- Controls:
- no
- Amount / concentration applied:
- 1.00, 2.15, 4.64 and 10.0 gm/Kg of body weight.
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 4 groups of 4 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema visual assessment
- Time point:
- other: end of exposure period
- Reversibility:
- fully reversible within: 2 - 5 days
- Remarks on result:
- other: Score not specified
- Irritation parameter:
- other: mild desquamation
- Time point:
- other: day 1-2 post exposure
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: no score was given
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hours not specified
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- other: 24/48/72 hours not specified
- Irritant / corrosive response data:
- Mild, diffuse erythema was the only irritative effect noted in animals upon completion of the exposure period. This subsided in 2-5 days. Mild desquamation was noted within 1 to 6 days and generally persisted through termination of the study.
Any other information on results incl. tables
Mild, diffuse erythema was the only irritative effect noted in animals upon completion of the exposure period. This subsided in 2-5 days. Mild desquamation was noted within 1 to 6 days and generally persisted through termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Cure-rite 18 did not cause local irritative effects, other than mild, diffuse erythema and mild desquamation, up to 10,000 mg/kg.
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