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EC number: 237-335-9 | CAS number: 13752-51-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April 2- April 10, 1981
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- 12 Sprague Dawley rats were obtained for the experiment. Nine were randomly assigned to the treated group and three assigned to the control group. After 1, 3 and 5 days, the whole blood was collected via venipuncture of the retro orbital sinus. Whole blood was separated into plasma and the plasma frozen until analysis. Bodyweight and food consumption were recorded. One control rat was sacrificed on Day 1, 3 and 5 along with 3 animals from the control group.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Duration and frequency of treatment / exposure:
- Up to 5 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
600 ppm
- No. of animals per sex per dose / concentration:
- 3 total per dose
- Control animals:
- yes, plain diet
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. Reasonable stability of Cure-rite 18 in rat plasma for 14 days was demonstrated.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. Reasonable stability of Cure-rite 18 in rats plasma for 14 days was demonstrated. - Executive summary:
The purpose of this study was to determine the levels of Cure-rite 18 in rats administered Cure-rite 18 treated diets for up to 5 days.
Nine rats were randomly assigned to the treated groups and three rats were assigned to the control. After 1, 3 and 5 days the whole blood was collected and separated into plasma. One control rat was sacrificed on Day 1, 3 and 5 along with 3 animals from the treatment group.
No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. reasonable stability of Cure-rite 18 in rats plasma for 14 days was demonstrated.
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