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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
April 2- April 10, 1981
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Objective of study:
absorption
Principles of method if other than guideline:
12 Sprague Dawley rats were obtained for the experiment. Nine were randomly assigned to the treated group and three assigned to the control group. After 1, 3 and 5 days, the whole blood was collected via venipuncture of the retro orbital sinus. Whole blood was separated into plasma and the plasma frozen until analysis. Bodyweight and food consumption were recorded. One control rat was sacrificed on Day 1, 3 and 5 along with 3 animals from the control group.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(morpholinothio)thioxomethyl]morpholine
EC Number:
237-335-9
EC Name:
4-[(morpholinothio)thioxomethyl]morpholine
Cas Number:
13752-51-7
Molecular formula:
C9H16N2O2S2
IUPAC Name:
morpholin-4-yl morpholine-4-carbodithioate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Duration and frequency of treatment / exposure:
Up to 5 days
Doses / concentrations
Remarks:
Doses / Concentrations:
600 ppm
No. of animals per sex per dose / concentration:
3 total per dose
Control animals:
yes, plain diet

Results and discussion

Main ADME results
Type:
absorption
Results:
No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. Reasonable stability of Cure-rite 18 in rat plasma for 14 days was demonstrated.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. Reasonable stability of Cure-rite 18 in rats plasma for 14 days was demonstrated.
Executive summary:

The purpose of this study was to determine the levels of Cure-rite 18 in rats administered Cure-rite 18 treated diets for up to 5 days.

Nine rats were randomly assigned to the treated groups and three rats were assigned to the control. After 1, 3 and 5 days the whole blood was collected and separated into plasma. One control rat was sacrificed on Day 1, 3 and 5 along with 3 animals from the treatment group.

No significant absorption of Cure-rite 18 occurs when administered to rats at a dose of 600 ppm for 5 days. reasonable stability of Cure-rite 18 in rats plasma for 14 days was demonstrated.