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EC number: 237-335-9 | CAS number: 13752-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 18 - April 23, 1980
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 40 CFR 163.81-1
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
- Details on test material:
- Cure-Rite® 18, purity: not noted
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Animals from two suppliers were compared in this study
- Age at study initiation: 6 weeks
- Weight at study initiation: 109-202 grams
-Fasting period before study - approximately 18 hours
- Housing: Group house (6/cage) during equilibration. Individually housed during study.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7-8-days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 69 - 75°F
- Photoperiod (hrs dark / hrs light): 12 dark/12 light
IN-LIFE DATES: From: 25 March 1980 To: 23 April 1980
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5 g/ml (50%)
- Purity: not recorded
MAXIMUM DOSE VOLUME APPLIED: 18.2 mL/kg bodyweight - Doses:
- mg/kg
0, 25, 50, 100, 1800, 2700, 4050, 6075, 9112 - No. of animals per sex per dose:
- Doses 0-100 mg/kg - 10 animals per sex
Doses 1800-9112 mg/kg - 5 animals per sex - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days. 5 animals per sex in dose groups 0 to 100 mk/kg were held for 28 days
- Frequency of observations and weighing: Viability check - twice daily. Observation of Pharmacologic and Toxicologic signs made approximately 1,2 and 4 hours after dosing and daily thereafter for 14 daysand 28 days for 5 animals/sex in dose groups 0 to 100 mg/kg.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 200 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 200 - 6 200
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 4 800 - 6 200
- Mortality:
- Mortality due to the administration of test substance was not observed in the groups receiving doses of 25, 50 or 100 mg/kg.
0/10 rats died in the 1800 mg/kg dose group
1/10 rats died in the 2700 mg/kg dose group
1/10 rats died in the 4050 mg/kg dose group
9/10 rats died in the 6075 mg/kg dose group
8/10 rats died in the 9112 mg/kg dose group - Clinical signs:
- other: other: 25 to 100 mg/kg dose groups: a clear ocular discharge for 2-4 hours post treatment. Several rats at 100 mg/kg displayed a motor activity decrease which was most marked at 4 hours. There were no delayed effects induced in those animals sacrificed a
Any other information on results incl. tables
Results for individual sexes/suppliers are shown below as mg/kg with 95% confidence limits:
Supplier 1:
Male 5000 (+/-1600), Female 5500 (+/-2500), Total 5200 (+/-1000)
Supplier 2:
Male 6100 (1300 +/-), Female 4.3 (1800 +/-), Total 5000 (+/-1200)
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a study of the acute oral toxicity of Cure-Rite 18 to rats from two different sources of supply, total (male and female) LD50 values calculated were
5200 mg/kg and 5000 mg/kg. 95% confidence limits were +/- 1000 and +/- 1200 mg/kg respectively. - Executive summary:
5 groups of ten rats (five male and five female) were dosed at the following concentration: 1800, 2700, 4050, 6075 and 9112 mg test substance/kg bodyweight by oral gavage, then observation for mortality and clinical signs performed over a period of 14 days. At the end of the observation period, all animals were sacrificed and postmortem examinations performed. 0/10 rats died in the 1800 mg/kg dose group 1/10 rats died in the 2700 mg/kg dose group, 1/10 rats died in the 4050 mg/kg dose group, 9/10 rats died in the 6075 mg/kg dose group, 8/10 rats died in the 9112 mg/kg dose group. A considerable number of physical observations noted during the 14 day observation period. The most common findings were decreased respiratory rate and clear ocular, oral or nasal discharge.
The acute lethal oral dose to rats of Cure-rite 18 was found to be 5,000 mg/kg bodyweight for rats from 1 supplier and 5,200 mg/kg bodyweight for rats from a second supplier.
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