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EC number: 237-335-9 | CAS number: 13752-51-7
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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- Long-term toxicity to aquatic invertebrates
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Regulations for the Enforcement of the Federal Hazardous Substances act (September 17 1964)
- Principles of method if other than guideline:
- To measure the toxic effect after 1 hour inhalation to 10 male albino rats.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
- Reference substance name:
- Good-Rite® 3030x18 (Cure-Rite® 18); purity: not noted
- IUPAC Name:
- Good-Rite® 3030x18 (Cure-Rite® 18); purity: not noted
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- rats were exposed to the test material in an inhalation chamber for one hour, at a determined concentration of 164.4mg/L.
Chamber - plexiglass jar fitted with plexiglass lid. Lid contained air intake and exit tubes positioned at the top and bottom of the chamber
respectively. Sample was introduced into the chamber atmosphere by leading the intake air to the bottom of a filter flask containing the sample. The
air stream was directed tangentially against the walls of the flask to produce a swirling motion. The air flow with entrained sample was then directed into the chamber atmosphere. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- 164.4 mg/L
- No. of animals per sex per dose:
- 10 males in one group.
- Control animals:
- no
- Details on study design:
- Exposure was 1 hour to the rats in the chamber. Rats were then housed in wire mesh cages suspended above the droppings. Observations were made continuously of the appearance and behaviour of the animals during the exposure period and at frequent intervals thereafter for the total 14 days.
at end of observation period, rats were weighed, sacrificed by cerebral concussion and gross necropsies were performed.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 164.4 mg/L air (nominal)
- Based on:
- test mat.
- Remarks:
- Cure-rite 18
- Exp. duration:
- 1 h
- Remarks on result:
- other: no confidence limits were calculated during this study
- Mortality:
- No mortalities occurred in the group of 10 male rats.
- Clinical signs:
- other: serosanguineous lacrimation and nasal discharge was noted in occasional rats in first few days of the study. Followed by normal appearance for the remainder of the 14 day observation period.
- Body weight:
- Average body weight gain of 52 grams which is within normal limits for rats of the age, sex and strain used.
- Gross pathology:
- no pathological alterations.
- Other findings:
- observations included "excited" activity upon initiation and intermittent preening, excessive masticatory movements, slight excessive lacrimation,
rapid respiration and hair coats covered with sample dust throughout the hour. Cloudiness of the chamber atmosphere prevented more detailed
observations.
Removal from the chamber - observations showed sample covered hair coats and excessive lacrimation in all rats, and excessive salivation in five
rats. First few days showed serosanguineous lacrimation or nasal discharge and afterwards the rats appeared normal throughout the 14 day
observation period.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Study Director Approval
- Conclusions:
- The acute inhalation LC50 for 3030x18 is found to be greater than 164.4 mg/L.
- Executive summary:
Ten male rats were exposed by whole body exposure to an atmosphere containing the test material as an airborne dust for an exposure period of one hour. Following the exposure process, animals were observed for 14 days, sacrificed, then a necroscopic examination performed.
There were no deaths during the study. Test substance residues were seen on the fur of most of the exposed rats. Serosanguineous lacrimation and nasal discharge was noted in occasional rats in first few days of the study. Followed by normal appearance for the remainder of the 14 day observation period. Gross necropsy revelaed no pathological alterations.
The1-hour LC50 was estimated to be in excess of 164.4 mg/L of air.
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