Registration Dossier
Registration Dossier
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EC number: 237-335-9 | CAS number: 13752-51-7
Endpoint summary
Administrative data
Description of key information
Cure-rite 18 is not irritant for the eye or the skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In one study for the evaluation of the eye irritancy of Cure-rite 18 (Biosearch Incorporated 1981, 81-2738A), 9 rabbits were exposed to 100mg of substance in the eye with and without washing 30sec or 1 min after application. 6 animals of the unwashed treated eyes had a total ocular irritation score between 2 - 8 on day 1, followed by a score of 0 by day 7. 3 animals of the washed treated eyes had a total ocular irritation score of 0 on day 1 - 7.
In conclusion, Cure-rite 18 is not an eye irritant.
In a second test (Hill Top Research Inc. 1971, V-918), 100mg of Cure rite 18 was applied on 6 rabbits eye, without washing. Examination for irritation occurred at 24, 48, and 72 hours after application.
Mild to marked corneal opacity and mild or moderate conjunctivitis in the remaining 5 animals. Blanching of the bulbar conjunctivae of 3 rabbits, a film like covering over the eyeball of one rabbit and mild iritis in one rabbit are also noted. Irritative effects subsided completely in one rabbit, but persisted through the 72-hour reading in the remaining 4 rabbits.
This result is explained by the exposure time and the absence of washing.
The skin irritation potential was assessed during the acute dermal toxicity study. No local irritative effects were noted in any animal upon completion of the exposure period at upto 10,000 mg/kg. Mild desquamation was noted within 1 to 6 days and gernerally persisted through termination of the study.
Justification for classification or non-classification
Cure-rite 18 is not irritant for the skin or for the eye, and should not be classified for irritation.
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