Registration Dossier
Registration Dossier
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EC number: 603-923-2 | CAS number: 135590-91-9
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Assessment of PBT/vPvB Properties - Comparison with the Criteria of Annex XIII
Persistence Assessment
Mefenpyr-diethyl is not readily biodegradable in accordance with the definition given in the OECD Guidelines for the Testing of Chemicals, but Mefenpyr-diethyl is rapidly degraded by microbial induced processes. The metabolic pathway is similar for both water/sediment systems tested. Based on the results of the studies, there is no potential for a persistence of Mefenpyr-diethyl in the aquatic environment.
Additionally, tests on aerobic and anaerobic transformation in soil show half- lives to be significantly below 120 days. The route of degradation of Mefenpyr-diethyl in aerobic soil proceeded via a fast hydrolytical step to result in half-lives of degradation to range from 1 – 3 days at 20°C and to be less than one week at 10°C. In comparison, no degradation was observed in sterilised soil.
Therefore Mefenpyr-diethyl is not persistent and does not meet the P criterion.
Bioaccumulation Assessment
Results of astudy reveal that Mefenpyr-diethyl does not show significant accumulation in aquatic organisms. Due to rapid depuration, the potential for biomagnification through the food chain is low as indicated by a flow-through bioaccumulation and metabolism study with Bluegill Sunfish (Lepomis macrochirus) with a(whole fish) of 232. Following uptake the depuration of residues in fish in clean water is fast (> 95 % in 3 days) and complete. The available information indicates that Mefenpyr-diethyl has a very low potential for bioconcentration and will not accumulate to significant levels in aquatic organisms.
Therefore Mefenpyr-diethyl does not meet the B criterion.
Toxicity Assessment
From the ecotoxicity perspective the toxicity criterion is not met for Mefenpyr-diethyl with a lowest NOEC of 0.1 mg a.s./L (fish) being clearly beyond the ecologically relevant EC or LC triggers of less than 0.01 mg/L. All data give comparable results for fish and aquatic plants.
The substance is not classified as carcinogenic, mutagenic or toxic for reproduction nor is there any evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC.
Therefore Mefenpyr-diethyl does not meet the T criterion
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