Registration Dossier
Registration Dossier
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EC number: 603-923-2 | CAS number: 135590-91-9
Endpoint summary
Administrative data
Description of key information
Additional information
The environmental profile of the substance is well defined. Short-term and long-term tests with species of three trophic levels are available for the parent substance and different metabolites of the parent.
The effect concentrations recorded for the parent substance are generally lower compared to the effect values determined for the different metabolites.
Fish turned out to be the most sensitive organisms group in acute and chronic toxicity testing. The LC50 (96 h) determined in a short-term study according to OECD guideline 203 on mirror carp was 2.4 mg/L (nominal). The effect concentrations determined for aquatic invertebrates were in the same order of magnitude. For Daphnia magna an EC50 (48 h) of 5.9 mg/L (measured) was determined. The EC50 (96 h) based on the growth rate of green algae was 10.71 mg/L based on the measured substance concentration. The related NOEC (96 h) was 2.86 mg/L (measured). A 28-day Juvenile Fish Growth Test according to OECD 215, conducted under flow-through conditions, determined a NOEC (28 d) of 0.1 mg/L for chronic toxicity to fish. In the key long-term study on Daphnia magna a NOEC (21 d) of 0.32 mg/L (nominal) was determined based on reproduction and offspring survival.
The 3-h EC50 of the test substance for respiratory inhibition of activated sludge was > 1000 mg/L, the limit dose for this type of study. This indicates a low toxicity of the substance to sludge microorganisms and inhibition of the degradation activity of activated sludge is not anticipated.
In the natural environment (soil, water) the substance is quickly metabolized. Degradation takes place via successive hydrolysis at one of the two ester functions of the parent molecule, followed by decarboxylation and aromatization as the major steps of degradation, therefore a long term exposure of the aquatic environment is not expected.
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