Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Generally, following values have been reported for the LC50 after 96h exposure time:
LC50 96h: 1.0 - 4.8 mg/L
Long-term toxicity to fish
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Generally, following values have been reported for the long-term toxicity to fish:
NOEC: 0.04 - 0.5 mg/L
LOEC: 0.18 mg/L
The values were obtained with respect to different guidelines and exposure times.
Short-term toxicity to aquatic invertebrates
Weight of Evidence: The EC50/LC50 values obtained from these studies are in the same order of magnitude.
48h-EC50: 1.4 - 50.2 mg/L
The most conservative EC50 of 1.4 mg/l (NITE, 2009) was obtained after 48h.
Long-term toxicity to aquatic invertebrates
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Generally, following NOEC values have been reported for the long-term toxicity to aquatic invertebrates:
NOEC: 0.064 - 0.7 mg/L
Toxicity to aquatic algae and cyanobacteria
Weight of Evidence: The EC50 and NOEC values obtained from these studies are in the same order of magnitude.
72h-EC50: 1.46 - 32 mg/L
72h-NOEC: 2.2 mg/L
96h-EC50: 1.4 mg/L
96h-NOEC: 0.37 - 1.46 mg/L
The most conservative EC50 of 1.4 mg/l (Calamari et al., 1983) and NOEC value of 0.37 mg/L (Calamari et al., 1983) were both obtained after 96h.
Toxicity to microorganisms
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Generally, following EC50 values have been reported for the toxicity to microorganisms:
EC50: 0.91 - 500 mg/L
The values were obtained under different test conditions. It is not always stated whether and which guideline was used.
Toxicity to other aquatic invertebrates
For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".
Studies were performed in different test species (Tetrahymena pyriformisan, Branchiostoma caribaeum, Artemia salina, Tanytarsus dissmilis, Aplexa hypnorum), with varying exposure times and revealed following values:
EC50: 0.91 - 3.16 mg/L
LC0: 1.5 mg/L
LC100: 10 mg/L
Additional information
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