1,2,4-trichlorobenzene

Toxicity to soil macroorganisms except arthropods

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

toxicity to soil macroorganisms except arthropods, other

Type of information:

other: EU Risk Assessment

Adequacy of study:

other information

Reliability:

other: EU Risk Assessment

Rationale for reliability incl. deficiencies:

other: No reliability is given as this is a summary entry for the EU RAR.

Principles of method if other than guideline:

EU Risk Assessment

GLP compliance:

not specified

EU Risk Assessment (2003):

 

The reported EC50 values range between 127 mg/kg (Neuhauser et al., 1986) and 290 mg/kg (Ballhorn et al., 1984).

 

The toxicity to earthworms was studied using the OECD artificial soil test. In the same study, contact tests were performed in which LC50 values of 23 -27µg/cm2 were observed (Neuhauser et al., 1986). In a study on Eisenia foetida over 14 days, an EC50 was observed at 290 mg/kg soil dry weight. The EC0 was 100 mg/kg. The substance was applied dissolved in acetone and nominal concentrations used in the effect estimations (Ballhorn et al., 1984).

Executive summary:

EU Risk Assessment (2003):

 

The reported EC₅₀ values range between 127 mg/kg (Neuhauser et al., 1986) and 290 mg/kg (Ballhorn et al., 1984).

 

The toxicity to earthworms was studied using the OECD artificial soil test. In the same study, contact tests were performed in which LC₅₀ values of 23 -27µg/cm² were observed (Neuhauser et al., 1986). In a study on Eisenia foetida over 14 days, an EC₅₀ was observed at 290 mg/kg soil dry weight. The EC₀ was 100 mg/kg. The substance was applied dissolved in acetone and nominal concentrations used in the effect estimations (Ballhorn et al., 1984).

Reference 2

Endpoint:

toxicity to soil macroorganisms except arthropods, other

Type of information:

other: BUA report

Adequacy of study:

other information

Reliability:

other: BUA report

Rationale for reliability incl. deficiencies:

other: No reliability is given as this is a summary entry for the BUA report.

Principles of method if other than guideline:

BUA report

GLP compliance:

not specified

BUA report (1987):

 

In a study on filter paper 1,2,4-TCB was found to be very toxic toEisenia foetida. The LC50 ranged between 10 - 100 µg/cm² (Neuhauser et al., 1986).

 

In an OECD-Guideline study following results were found: LC0 = 125 mg/kg, LC50 = 250-500 mg/kg and LC100 = 500 mg/kg (Broecker et al., 1984).

Executive summary:

BUA report (1987):

 

In a study on filter paper 1,2,4-TCB was found to be very toxic toEisenia foetida. The LC₅₀ ranged between 10-100 µg/cm² (Neuhauser et al., 1986).

 

In an OECD-Guideline study following results were found: LC₀=125 mg/kg, LC₅₀=250-500 mg/kg and LC₁₀₀=500 mg/kg (Broecker et al., 1984).

Description of key information

For transported isolated intermediates according to REACh, Article 18, this endpoint is not a data requirement. However, data is available for this endpoint and is thus reported under the guidance of "all available data".

 

EU Risk Assessment (2003):
The reported EC50 values range between 127 mg/kg (Neuhauser et al., 1986) and 290 mg/kg (Ballhorn et al., 1984).
The toxicity to earthworms was studied using the OECD artificial soil test. In the same study, contact tests were performed in which LC50 values of 23 -27µg/cm2 were observed (Neuhauser et al., 1986). In a study on Eisenia foetida over 14 days, an EC50 was observed at 290 mg/kg soil dry weight. The EC0 was 100 mg/kg. The substance was applied dissolved in acetone and nominal concentrations used in the effect estimations (Ballhorn et al., 1984).

BUA report (1987):
In a study on filter paper 1,2,4-TCB was found to be very toxic toEisenia foetida. The LC50 ranged between 10-100 µg/cm² (Neuhauser et al., 1986).
In an OECD-Guideline study following results were found: LC0=125 mg/kg, LC50=250-500 mg/kg and LC100=500 mg/kg (Broecker et al., 1984).