Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Contact sensitivity of phenylglycidyl ether
- Author:
- Rudzki E and Krajewska D
- Year:
- 1 979
- Bibliographic source:
- Dermatosen 27, 42-44
- Reference Type:
- secondary source
- Title:
- Toxicological Evaluations 3 - Potential health hazards of existing chemicals
- Author:
- BG Chemie
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was rubbed onto the skin of guinea-pigs for 34 days, no further information given.
- Type of study:
- Buehler test
Test material
- Reference substance name:
- phenyl glycidyl ether
- IUPAC Name:
- phenyl glycidyl ether
- Details on test material:
- - Name of test material (as cited in study report): phenyl glycidyl ether
No further information.
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: epicutaneous
- Vehicle:
- other: ethanol
- Concentration / amount:
- 5%
Challengeopen allclose all
- Route:
- other: epicutaneous
- Vehicle:
- other: ethanol
- Concentration / amount:
- 5%
- No. of animals per dose:
- 10
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- Frequency of exposures: 6 days/week
- Exposure period: 34 days
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: no data
- Exposure period: no data
- Concentrations: 1%
No further information. - Challenge controls:
- no data
- Positive control substance(s):
- not specified
Results and discussion
Any other information on results incl. tables
All 10 animals responded to topical challenge with 1 % of the test substance.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
