2,3-epoxypropyl phenyl ether

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference Type:

publication

Title:

Occupational sensitization to epoxy resin and reactive diluents in marble workers

Author:

Angelini G, Rigano L, Forti C, Grandolfo M, Vena GA, Bonamonte D, Soleo L, Scorpinti AA

Year:

1996

Bibliographic source:

Contact Dermatitis 35, 11-16

Materials and methods

Endpoint addressed:

dermal absorption

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Marble workers handling a bicomponent resin, based on epoxy resin and ortho-cresyl glycidyl ether (CGE), were investigated for their development of a contact dermatitis and airborne contact dermatitis within 20 days to 2 month of exposure.

Test material

Test material information

Constituent 1

Reference substance name:

phenyl glycidyl ether

IUPAC Name:

phenyl glycidyl ether

Details on test material:

- Name of test material (as cited in study report): phenyl glycidyl ether
No further information.

Method

Ethical approval:

not specified

Details on study design:

2 months after the regular use of epoxy resin was introduced, 10 of 22 workers complained of the onset of pruriginous dermatitis and 2 of them also asthmatic manifestations. All 22 workers, symptomatic and not, were referred for investigation and assessment of suitable compensation. Anamnesis and clinical examination suggested that the dermatitis was work-related. All subjects were patch tested with the European standard series, bisphenol A, epichlorohydrin, ortho-cresyl glycidyl ether (CGE) and other reactive diluents.