2,3-epoxypropyl phenyl ether

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable study with restrictions (limited documentation)

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Range-finding toxicity data: List V

Author:

Smyth HF, Carpenter CP, Weil CS, Pozzani UC

Year:

1954

Bibliographic source:

Arch. Ind. Hyg. Occupational Med. 10, 61-68

Reference 2

Reference Type:

secondary source

Title:

Epoxy Compounds. In Patty's Industrial Hygiene and Toxicology

Author:

Hine C, Rowe VK, White ER, Darmer KI JR, Youngblood GT

Year:

1981

Bibliographic source:

Patty's Industrial Hygiene and Toxicology, 3rd ed., Vol. 2A, Ch. 32, 2197-2257

Reference 3

Reference Type:

secondary source

Title:

Experimental Carcinogenicity and Acute Toxicity of Repesentative Epxoides

Author:

Weil CS, Condra N, Haun C, Striegel JA

Year:

1963

Bibliographic source:

Industrial Hygiene Journal, 305-325

Reference 4

Reference Type:

secondary source

Title:

Epoxy Compounds

Author:

Waechter JM et al.

Year:

2001

Bibliographic source:

Patty´s Toxicology, fifth edition, vol. 6, 1063-1085

Reference 5

Reference Type:

secondary source

Title:

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Author:

WHO IARC

Year:

1989

Bibliographic source:

IARC Monographs, Volume 47, 237-261

Reference 6

Reference Type:

secondary source

Title:

Phenyl glycidyl ether

Author:

MAK Commission

Year:

1991

Bibliographic source:

MAK List 1991

Report date:

1991

Materials and methods

Principles of method if other than guideline:

Primary skin irritation on rabbits was recorded in a 10-grade ordinal series with the severest reaction on the clipped skin of rabbits within 24 hours of application of 0.01 ml of undiluted sample or of dilutions in water, propylene glycol, or kerosene.

Test material

Test material information

Constituent 1

Reference substance name:

phenyl glycidyl ether

IUPAC Name:

phenyl glycidyl ether

Details on test material:

- Name of test material (as cited in study report): phenyl glycidyl ether
No further information.

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

No data.

Test system

Type of coverage:

not specified

Preparation of test site:

shaved

Vehicle:

other: water, propylene glycol, or kerosene

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.01 ml of undiluted sample or of dilutions in water, propylene glycol, or kerosene
No further information.

Duration of treatment / exposure:

24 hours

Observation period:

No data.

Number of animals:

5

Details on study design:

SCORING SYSTEM: Skin irritation on rabbits was recorded in a 10-grade ordinal series. Grade 1 indicates the least visible capillary injection from undiluted chemical. Grade 6 indicates necrosis when undiluted, and Grade 10 indicates necrosis from a 0.01 % solution.