Registration Dossier
Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effect on aquatic microorganisms up to the limit of water solubility. Read across
Key value for chemical safety assessment
Additional information
Data on the toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to aquatic microorganisms are not available. In accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the
structurally related substances decanoic acid, mixed esters with
heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No.
71010-76-9) and Fatty acids, C7, C8, C10 and 2-ethylhexanoic acid,
tetraesters with pentaerythritol (CAS 68424-31-7) was conducted. This
read-across is justified in detail in the overall summary (IUCLID
section 6.2) and within the analogue justification in IUCLID Section 13.
One study investigating the toxicity of decanoic acid, mixed esters with
heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No.
71010-76-9) to aquatic microorganisms is available (Dickinson, 2008).
The GLP study was conducted under static conditions according to OECD
209 using non-adapted activated sludge obtained from a domestic sewage
treatment plant as inoculum. Test concentrations of 10, 100 and 1000
mg/L were prepared. Test substance was added directly to the test
vessels. The test substance did not inhibit the respiration rate of
activated sludge microorganisms at any of the concentrations employed in
the test. Hence, the 3 h-EC50 was determined to be > 1000 mg/L based on
the nominal test concentration. Therefore it can be concluded that the
test substance will not exhibit effects on the respiration rate of
microorganisms.
The toxicity of Fatty acids, C7, C8, C10 and 2-ethylhexanoic acid,
tetraesters with pentaerythritol (CAS 68424-31-7) to aquatic
microorganisms was tested in a cell multiplication inhibition test
according to Bringman and Kuehn (1980) (Comber and Coleman, 1991). No
inhibition on the growth of Pseudomonas putida was observed at the
tested concentration (10 mg/L nominal). Therefore an EC10 and EC50 (6h)
> 10 mg/L (nominal) was determined. Based on the available results from
two structurally related read-across substances (in accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a
similar ecotoxicological profile and comparable structure, it can be
concluded that 2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl
bisheptanoate (CAS 25811-35-2) will not exhibit short-term effects on
aquatic microorganisms up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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