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EC number: 247-279-7 | CAS number: 25811-35-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility. Read across.
Key value for chemical safety assessment
Additional information
Data on the short-term toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to aquatic organisms are not available. Thus, in accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the
structurally related substance fatty acids, C5-9 tetraesters with
pentaerythritol (CAS 67762-53-2) was conducted. This read-across is
justified in detail in the overall summary (IUCLID section 6.1) and
within the analogue justification in IUCLID Section 13.
The short-term toxicity of fatty acids, C5-9 tetraesters with
pentaerythritol (CAS 67762-53-2) to aquatic invertebrates was
investigated in a limit test according to OECD 202 under GLP conditions
(Migchielsen, 2012). Daphnia magna were exposed to the substance under
static conditions for 48 hours. A water accommodated fraction (WAF) of
100 mg/L (nominal) corresponding to a measured concentration of 1.3
mg/L, was tested. No immobilisation was observed in the treatment
throughout the test period of 48 h. Hence, the 48 h-EL50 is determined
to be > 100 mg/L based on the nominal test concentration and > 1.3 mg/L
based on the measured concentration. Thus, the substance is not expected
to by acutely toxic to aquatic invertebrates up to the limit of water
solubility. Based on the available results from a structurally related
read-across substance (in accordance to Regulation (EC) No 1907/2006
Annex XI, 1.5) which is characterized by a similar ecotoxicological
profile and comparable structure, it can be concluded that
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) will not exhibit short-term effects on aquatic invertebrates
up to the limit of water solubility.
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