Registration Dossier
Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: 76 - 96% after 28 d (OECD 301B); read-across
Key value for chemical safety assessment
Additional information
Data on the ready biodegradability of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) are not available. Therefore, in accordance to Regulation
(EC) No 1907/2006 Annex XI, 1.5, data on the ready biodegradability of
the structurally related substances pentaerythritol tetraesters of
n-decanoic, n-heptanoic, n-octanoic and n-valeric acids (CAS 68424-31-7)
and fatty acids, C16-18 and C18-unsatd., tetraesters with
pentaerythritol (CAS 68604-44-4) is used as read-across. This
read-across is justified in detail in the overall summary (IUCLID
section 6.1) and within the analogue justification in IUCLID Section 13.
The biodegradability of pentaerythritol tetraesters of n-decanoic,
n-heptanoic, n-octanoic and n-valeric acids (CAS 68424-31-7) was tested
in a study conducted according to OECD guideline 301B (Häner, 2006).
Activated sludge was exposed to the test substance for 28 days. The
biodegradation rate was determined by measuring the CO2 evolution. After
28 days, the test substance reached a degradation rate of 96%. In a
second study following OECD guideline 301B conducted with
pentaerythritol tetraesters of n-decanoic, n-heptanoic, n-octanoic and
n-valeric acids (CAS 68424-31-7) a biodegradation rate of 78% was
determined after 28 days (Muckle, 2009). Therefore the substance was
regarded as readily biodegradable according to the OECD criteria. In a
third study the biodegradability of fatty acids, C16-18 and C18-unsatd.,
tetraesters with pentaerythritol (CAS 68604-44-4) was tested according
to OECD guideline 301B (Häner, 2007). The substance was degraded by 76%
after 28 days and thus regarded as readily biodegradable according to
the OECD criteria.
Thus, based on the available studies from structurally related
read-across substances (in accordance to Regulation (EC) No 1907/2006
Annex XI, 1.5) which are characterized by an equal ecotoxicological
profile and a similar structure, it can be concluded that
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) is readily biodegradable according to the OECD criteria.
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