Registration Dossier
Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic algae up to the limit of water solubility. Read across
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to aquatic algae are not available. In accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the
structurally related substances fatty acids, C8-10 mixed esters with
dipentaerythritol, isooctanoic acid, pentaerythritol and
tripentaerythritol (CAS 189200-42-8) and fatty acids, C16-18 (even
numbered), esters with pentaerythritol (CAS-No. 85116-93-4) was
conducted. This read-across is justified in detail in the overall
summary (IUCLID section 6.1) and within the analogue justification in
IUCLID Section 13.
The toxicity of fatty acids, C8-10 mixed esters with dipentaerythritol,
isooctanoic acid, pentaerythritol and tripentaerythritol (CAS
189200-42-8) to algae was tested in a study according to OECD 201 under
GLP conditions (Febbo, 1995). The green algae Scenedesmus capricornutum
was exposed to nominal concentrations of 62.5 mg/L, 125 mg/L, 250 mg/L,
500 mg/L and 1000 mg/L. No inhibition of growth of Scenedesmus
capricornutum up to the limit of water solubility was observed resulting
in an EL50 > 1000 mg/L (nominal). A NOELR of ≥ 1000 mg/L (nominal) was
determined based on effects on growth rate. Comparable results were
obtained by a study investigating the toxicity of fatty acids, C16-18
(even numbered), esters with pentaerythritol (CAS-No. 85116-93-4) to
algae. This static algal growth inhibition test with Pseudokirchnerella
subcapitata was conducted according to GLP, and EPA OPPTS 850.5400
(Algal Toxicity, Tiers I and II). An ErL50 and ErL10 (72h) of > 100 mg/L
was determined (WAF loading rate). Toxic effects on algae are not
expected up to the water solubility for the read-across substance. Based
on the available results from two structurally related read-across
substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5)
which are characterized by a similar ecotoxicological profile and
comparable structure, it can be concluded that
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) will not exhibit short-term effects on aquatic algae up to
the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
