Registration Dossier
Registration Dossier
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EC number: 247-279-7 | CAS number: 25811-35-2
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
No effects of the test substance on terrestrial organisms are expected.
Key value for chemical safety assessment
Additional information
Studies investigating the toxicity of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) to soil macroorganisms are not available. Therefore, in
accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across
to three structurally related substances decanoic acid, mixed esters
with heptanoic acid, octanoic acid, pentaerythritol and valeric acid
(CAS 71010-76-9), fatty acids, C16-18 and C18-unsatd., tetraesters with
pentaerythritol (CAS 68604-44-4) and fatty acids, C16-18 and
C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) was
conducted. This read-across is justified in detail in the overall
summary (IUCLID section 6.3) and within the analgoue justification in
IUCLID Section 13.
An acute test following OECD 207 is available for the read across
substance decanoic acid, mixed esters with heptanoic acid, octanoic
acid, pentaerythritol and valeric acid (CAS No. 71010-76-9; Kelley,
2013). Eisenia fetida was exposed to a test concentration of 1000 mg/kg
dw in artificial soil for 14 days. A survival rate of 100% was observed
in both the control group and treatment group. Thus, based on earthworm
mortality, a NOEC (14 d) ≥ 1000 mg/kg dw was determined. The available
studies for the read across substances fatty acids, C16-18 and
C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) and fatty
acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS
85711-45-1) were conducted according to OECD 222 (Amsel, 2013a,b). In
both long-term studies, Eisenia andrei was exposed to a test
concentration of 1000 mg/kg dw in artificial soil for 56 days. Mortality
and reproduction rate were recorded at study termination. No effects
were observed resulting in a NOEC (28 d) of ≥ 1000 mg/kg dw based on
mortality and a NOEC (56 d) of ≥ 1000 mg/kg dw based on reproduction.
Based on the results from structurally related read-across substances
(in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are
characterized by an equal ecotoxicological profile toxic effects of
2,2-bis[[(1-oxoheptyl)oxy]methyl]propane-1,3-diyl bisheptanoate (CAS
25811-35-2) on soil macroorganisms are not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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