(3-methacrylamidopropyl)trimethylammonium chloride

Long-term toxicity to aquatic invertebrates

Description of key information

The 21 day EC10 of MAPTAC in freshwater invertebrates based on reproductive effects was 53.6 mg a.i./L. The 21-day NOEC of MAPTAC in freshwater invertebrates based on reproduction was 50.6 mg a.i./L (OECD guideline 211). 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

53.6 mg/L

Additional information

One long-term study in freshwater invertebrates is available for MAPTAC, which is considered reliable without restriction (Klimisch score 1).

 

The 21-day-chronic toxicity of MAPTAC (50.6% in aqueous solution) to Daphnia magna Straus was studied under static renewal conditions according to OECD guideline 211 (adopted 3 October 2008). Daphnids were exposed to control and test chemical at nominal concentrations of 0 (control), 50.0, 100, 200, 400 and 800 mg/L, corresponding to 0, 25.3, 50.6, 101, 202 and 404 mg a.i./L. Measured concentrations were within 95 and 106% of nominal concentrations. Therefore, all effect values given are based on the nominal concentrations of the test item.

The sublethal effects included were reproductive output, number of living offspring per parent, occurrence offirst brood, intrinsic rate of natural increase, occurrence of aborted eggs and stillborn juveniles and body length of the parental daphnids. 

Based on the biologically significant variation of the reproductive output at the concentration levels 200 and 400 mg/L, the No Observed Effect Concentration after 21 days was assessed at 100 mg test item/L (corresponding to 50.6 mg a.i./L) and the Lowest Observed Effect Concentration was assessed at 200 mg test item/L (corresponding to 101 mg a.i./L).

The test item induced biologically significantadult mortalityin concentration levels of 400 mg/L (60%) and 800 mg/L (100%) after 21 days.In the concentration levels 50.0 to 200 mg/L and in the control all parental daphnids survived till the end of the test after 21 days.

The 21 day EC10 based on adult mortality was 140 mg a.i./L (95% CL 137 to 144 mg a.i./L). The 21 day EC10 based on reproductive effects was 53.6 mg a.i./L (95% CL <25.3 – 76.4 mg a.i./L).

The 21-day NOEC based on adult mortality was 101 mg a.i./L. The 21-day NOEC based on reproduction was 50.6 mg a.i./L.