Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 257-182-1 | CAS number: 51410-72-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published, generally valid scientific method
Data source
Reference
- Reference Type:
- publication
- Title:
- High performance liquid chromatographic determination of methacrylate in blood serum
- Author:
- Bereznowski Z, Mariewski M, Somolenski RT
- Year:
- 1 994
- Bibliographic source:
- Biomed. Chromatogr., 8, 42-44
Materials and methods
- Objective of study:
- other: adsorption and development of analytical method
- Principles of method if other than guideline:
- The test material was administered by gavage and analytically determined in blood
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium methacrylate
- EC Number:
- 226-896-5
- EC Name:
- Sodium methacrylate
- Cas Number:
- 5536-61-8
- IUPAC Name:
- sodium methacrylate
- Reference substance name:
- Methacrylic acid, sodium salt
- IUPAC Name:
- Methacrylic acid, sodium salt
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- The test animals weighed 3-400 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- 2 ml of the test substance were administered as a 1 M aqueous solution.
- Duration and frequency of treatment / exposure:
- Animals were sacrificed at various(not specified) times after administration and blood was collected for determination of MAA.
- Details on dosing and sampling:
- Analysis by HPLC/UV-VIS; detection at 210/240 nM
LoQ: 0.5 µM
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- After a single oral administration of the sodium salt of methacrylic acid to Wistar rats (540 mg/kg bw) methacrylic acid was detected in the blood serum by means of HPLC. The maximum concentration was found after 10 min, whereas after 60 min no more methacrylic acid was detectable.
- Executive summary:
The presence of methacrylic acid (quantity not determined) was reported in Wistar rat blood serum 10 min after oral gavage administration of 2 ml of a 1 M solution of sodium methacrylate. After 60 min MAA could not anymore be detected in the blood serum (detection limit 0.5 µmol/l).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.