Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published, generally valid scientific method

Data source

Reference
Reference Type:
publication
Title:
High performance liquid chromatographic determination of methacrylate in blood serum
Author:
Bereznowski Z, Mariewski M, Somolenski RT
Year:
1994
Bibliographic source:
Biomed. Chromatogr., 8, 42-44

Materials and methods

Objective of study:
other: adsorption and development of analytical method
Principles of method if other than guideline:
The test material was administered by gavage and analytically determined in blood
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Sodium methacrylate
EC Number:
226-896-5
EC Name:
Sodium methacrylate
Cas Number:
5536-61-8
IUPAC Name:
sodium methacrylate
Constituent 2
Reference substance name:
Methacrylic acid, sodium salt
IUPAC Name:
Methacrylic acid, sodium salt

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
The test animals weighed 3-400 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on exposure:
2 ml of the test substance were administered as a 1 M aqueous solution.
Duration and frequency of treatment / exposure:
Animals were sacrificed at various(not specified) times after administration and blood was collected for determination of MAA.
Details on dosing and sampling:
Analysis by HPLC/UV-VIS; detection at 210/240 nM
LoQ: 0.5 µM

Results and discussion

Applicant's summary and conclusion

Conclusions:
After a single oral administration of the sodium salt of methacrylic acid to Wistar rats (540 mg/kg bw) methacrylic acid was detected in the blood serum by means of HPLC. The maximum concentration was found after 10 min, whereas after 60 min no more methacrylic acid was detectable.
Executive summary:

The presence of methacrylic acid (quantity not determined) was reported in Wistar rat blood serum 10 min after oral gavage administration of 2 ml of a 1 M solution of sodium methacrylate. After 60 min MAA could not anymore be detected in the blood serum (detection limit 0.5 µmol/l).