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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 December 2003 and 11 March 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study conducted in accordance with an internationally recognised method
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
The stock test solution was prepared in water and not octanol due to low solubility of the substance in n-octanol.
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
other: Ion chromatography - pyrophosphate analysis
Type:
log Pow
Partition coefficient:
-1.48
Temp.:
22 °C
pH:
6.9 - 7.2
Type:
log Pow
Partition coefficient:
< -4.18
Temp.:
22 °C
pH:
6.9 - 7.2

Sample Number

n-Octanol/Water Volume Ratio

Log Pow

 

 

Mean Log Pow

 

 

Organic component

1

2

3

4

5

6

 

 

7:1

7.1

31:1

31:1

15:1

15:1

 

-1.43

-1.37

-1.70

-1.52

-1.48

-1.45

 

 

 

 

-1.48

Inorganic

component

1

2

3

4

5

6

 

 

7:1

7.1

31:1

31:1

15:1

15:1

 

<-4.18

<-4.18

<-4.18

<-4.20

<-4.19
<-4.19

 

 

 

<-4.18

 

 
Conclusions:
The partition coefficient has been determined to be in the range -1.48 to <-4.18.

Description of key information

The partition coefficient has been determined to be in the range -1.48 to <-4.18.  The value of -1.48 is taken as the key value for the chemical safety assessment.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.48
at the temperature of:
22 °C

Additional information

The partition coefficient has been determined as -to be in the range 1.48 to <-4.18. The value of 1.48 (for the organic component of MPP) is to be taken forward for the risk assessment, on the basis that the inorganic (pyrophosphate) component will hydrolyse and form inorganic phosphate salts that are already widely present in the human body and in the environment.