Butanenitrile, 2-amino-2,3-dimethyl-

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, acceptable for assessment

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Materials and methods

Principles of method if other than guideline:

The substance was instilled into the conjunctival sac of the left eye at a dosage rate of 0.1 ml/rabbit. All surviving animals were retained for a 14-day observation period following treatment.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-amino-2,3-dimethylbutanenitrile

Cas Number:

13893-53-3

Molecular formula:

C6H12N2

IUPAC Name:

2-amino-2,3-dimethylbutanenitrile

Details on test material:

no data

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

Test animals: Male Albino rabbits

Test system

Vehicle:

unchanged (no vehicle)

Amount / concentration applied:

Application volume: 0.1 ml/rabbit
Doses (mg/kg)
Animal 1: 41.0
Animal 2: 42.2
Animal 3: 41.0
Animal 4: 39.7
Animal 5: 41.7
Animal 6: 39.5

Number of animals or in vitro replicates:

6

Results and discussion

In vivo

Other effects:

6/6 animals died within 11 minutes.