Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 604-102-1 | CAS number: 13893-53-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 83 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 340 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 23 mg/kg bw
Additional information
There are appropriate studies available for the acute toxicity of the oral and dermal route (similar to OECD guideline studies with acceptable deviations (no necropsy, limited reporting and without GLP) and for the inhalation of vapor (OECD guideline study with GLP).
Clinical signs observed were similar for all three routes and were described as tremors, tonic convulsions, salivation, hypoactivty, ataxia and prostration. As for the acute inhalation toxicity mortality occured within the time of exposure, i.e. 1 h or 4 h.
Justification for classification or non-classification
According to the criteria in Annex VI to 67/548/EEC data on the acute toxicity of butanenitrile, 2 -amino-2,3 -dimethyl warrant classification as "toxic" by the oral route and "very toxic" by the dermal route and inhalation of vapor.
According to the criteria in Annex I to the CLP regulation data on the acute toxicity of butanenitrile, 2 -amino-2,3 -dimethyl warrant classification in Category 1 for acute inhalation toxicity (vapor) and acute dermal toxicity as well as Category 3 for acute oral toxicity
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
