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EC number: 700-464-0 | CAS number: 99591-74-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide (MMDS) is rapidly hydrolized into methandisulphonic acid (MDSA) in water. Within 104 minutes, all MMDS hydrolized into MDSA. As the results of this, it is very difficult to prepare the test solution of MMDS. Therefore, according to the OECD guidance document, No.23, September 2000, "Guidance Document of Aquatic Toxicity testing of Difficult Substances and Mixtures", the toxicity study of Pseudokirchneriella subcapitata was conducted with MDSA. This study was performed according to the OECD 201 Guideline.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 42 mg/L
- EC10 or NOEC for freshwater algae:
- 31 mg/L
Additional information
The 72 -hour EC50 and NOEC without pH adjustments were 42 and 31 mg/L, resp. The EC50 and NOEC with pH adjustment were >100 and = 100 mg/L, resp. Therefore, it was considered that the effect to the test organisms was caused by low pH. The test substance concentrations in the test solution were maintained within ± 20% of the nominal concentrations during the exposure period. The test conditions were within the suitable range, therefore, it was concluded that this study complied with the applied test guidelines.
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