Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: Subchronic Dermal (90-Day) Exposure
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- National toxicology program technical report series no. 310: Toxicology and carcinogenesis studies of marine diesel fuel and JP-5 navy fuel in B6C3Fl mice (dermal studies).
- Author:
- NTP
- Year:
- 1 986
- Bibliographic source:
- Research Triangle Park, NC: National Toxicology Program/ National Institutes of Health. NIH publication no. 86-2566.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Subchronic Dermal (90-Day) Exposure
- Principles of method if other than guideline:
- Subchronic Dermal (90-Day) Exposure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- diesel fuel
- IUPAC Name:
- diesel fuel
- Details on test material:
- Test substance: mixtures of petroleum-derived products: marine diesel fuel (mixture of hydrocarbons containing 12.7% paraffins, 43.7% naphthalenes, and 43.6% aromatic compounds) and JP-5 jet aviation fuel (mixture of hydrocarbons containing 52.8% cycloparaffins, 30.8% paraffins, 15.9% aromatics, and 0.5% olefins)
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Study observed
Marine Diesel Fuel:
No histological changes were noted in the reproductive system of mice.
JP-5 navy fuel:
No histological changes were noted in the reproductive system of mice.
NOAEL (subchronic, mice, reproduction)= 4000 mg/kg bw/day –Marine Diesel Fuel
NOAEL (subchronic, mice, reproduction)= 8000 mg/kg bw/day –JP-5 navy fuel
Applicant's summary and conclusion
- Conclusions:
- Diesel Fuel did not induce damage to reproductive organs/ tissues of experimental animals
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