Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Diesel Fuel is an industrial chemical which is used in industrial closed systems only. The substance is not available to general public, and ingestion of Diesel Fuel is not anticipated. Therefore, inhalation of vapour/mist and/or dermal contact at industrial settings are the only possible exposure routes applicable to Diesel Fuel.
In accordance with the CLP Regulation criteria, a substance is classified as to its acute oral toxicity if LD50≤2 000 mg/kg bw. The QSAR estimated values for Diesel Fuel components report values of >2000 mg/kg bw suggesting low acute toxicity of this substance via oral exposure route.
The cut-off value for classification of substances for acute inhalation toxicity for aerosols/mists LC50= 5 mg/L. All published data for acute inhalation toxicity of Diesel Fuel report LC50 values higher than these values. It is, therefore, considered that Diesel Fuel is of low acute toxicity in experimental animals by inhalation.
Diesel Fuel products did not cause any mortality or clinical signs of toxicity when tested in mice via skin exposure at single doses of up to 40000 mg/kg bw. From the data on toxicokinetics, long carbon chain aliphatic hydrocarbons of petroleum origin have only limited absorption, including dermal exposure. Therefore, it is considered that Diese Fuel is of low acute toxicity by dermal exposure route.
Cases of accidental ingestions of petroleum-based products similar to Diesel fuels (e.g. kerosene) report symptoms of aspiration toxicity (pulmonary edema and difficulty in breathing), depression of nervous system and gastrointestinal irritation (ATSDR, 1995). Effects on nervous system were also seen in humans after inhalation to high vapour/aerosol concentrations of Fuel Oils.
Over all, Diesel Fuel is considered as being of low acute toxicity via oral, inhalation or dermal route. However, aspiration hazard is an important endpoint for acute exposure to this substance.
Because of Aspiration hazard, Diesel Fuel is classified as: Asp. Tox. Category 1 substance, H304: May be fatal if swallowed and enters airways.
Justification for classification or non-classification
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