Fuels, diesel

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference

Reference Type:

publication

Title:

Toxicological Profile for Fuel Oils

Author:

ATSDR

Year:

1995

Bibliographic source:

Agency for Toxic Substances and Disease Registry, June 1995

Materials and methods

Objective of study:

other: Science peer review report

Test guideline

Qualifier:

according to guideline

Guideline:

other: Science peer review report

Principles of method if other than guideline:

Science peer review report

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Hydrocarbons in the aromatic EC<9 fraction

IUPAC Name:

Hydrocarbons in the aromatic EC<9 fraction

Constituent 2

Reference substance name:

Hydrocarbons in the aromatic EC>9 –EC16 fraction:

IUPAC Name:

Hydrocarbons in the aromatic EC>9 –EC16 fraction:

Constituent 3

Reference substance name:

Hydrocarbons in the aliphatic EC5 –EC8 fraction:

IUPAC Name:

Hydrocarbons in the aliphatic EC5 –EC8 fraction:

Constituent 4

Reference substance name:

Hydrocarbons in the aliphatic EC>8 –EC16 fraction:

IUPAC Name:

Hydrocarbons in the aliphatic EC>8 –EC16 fraction:

Details on test material:

Data on individual components (fractions) of Diesel Fuel

Results and discussion

Any other information on results incl. tables

Data on individual components (fractions):

 

Hydrocarbons in the aromatic EC<9 fraction:

readily absorbed following inhalation or oral exposure, based on studies with humans and animals;

absorbed by the skin to a lesser extent, especially with exposure to vapors;

widely distributed throughout tissues and organs following absorption;

metabolized (via oxidative metabolic pathways involving cytochrome P-450) to more water-soluble metabolites that are excreted predominately in urine;

eliminated by exhalation of unchanged parent compound and urine and fecal excretion.

 

Hydrocarbons in the aromatic EC>9 –EC16 fraction:

may be absorbed following inhalation, oral, or dermal exposure, based on studies of humans and animals;

widely distributed following absorption;

metabolism involves aromatic ring oxidation;

urinary excretion of metabolites is the primary route of elimination.

 

Hydrocarbons in the aliphatic EC5 –EC8 fraction:

may be readily absorbed in the lungs, as indicated by studies of humans and animals;

absorption by the oral and dermal route is not well characterized;

widely distributed to tissues and organs with preferential partitioning into fatty tissues and well perfused tissues;

oxidatively metabolized predominately in the liver;

excreted in urine as metabolised form; exhaled unchanged.

 

Hydrocarbons in the aliphatic EC>8 –EC16 fraction:

absorption of aliphatic hydrocarbons (n-alkanes, isoparaffins, and naphthenes) is inversely related to molecular weight, ranging from complete absorption at the lower end of the molecular weight range to essentially no absorption for aliphatic hydrocarbons with >32 carbons;

widely distributed to tissues with preferential distribution and accumulation occurring in fatty tissues;

slowly eliminated.

Applicant's summary and conclusion

Conclusions:

The data on toxicokinetics of Diesel Fuel components/fractions suggest that short-chain hydrocarbons can be readily absorbed whereas long-chain aliphatic hydrocarbons have only limited absorption potential after inhalation, oral and ingestion exposure routes.

Depending on its chemical structure, absorbed hydrocarbons are widely distributed throughout tissues and organs, metabolised and excreted with urine and faeces, or exhaled unchanged.