Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 605-694-4 | CAS number: 173832-46-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
According to Regulation (EC) No. 1907/2006, Annex VII, 9.1.2, toxicity testing on algae species does not need to be conducted.
Key value for chemical safety assessment
Additional information
According to Regulation (EC) No. 1907/2006, Annex VII, 9.1.2, toxicity testing on algae species does not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur, for instance if the substance is highly insoluble in water or if the substance is unlikely to cross biological membranes. Fatty acids, C18 unsaturated, trimers, 2-ethylhexyl esters (CAS No. 173832-46-7) is poorly soluble in water (water solubility < 1 mg/L). Significant concentrations in the water phase are thus not expected to be reached, and the substance is not expected to be bioavailable for algae. Additionally, since the algal test (OECD 201) is a static test, the low water solubility and high adsorption potential (log Kow > 10) may critically hinder the technical feasibility of the study. Highly hydrophobic and adsorptive substances tend to adsorb to the walls of the test vessels and to the surface of algae cells, often causing effects on biomass and growth by direct physical interaction with the algae (e.g. hindering the access to light and nutrients, whereas dissolved concentrations in the test medium are actually close to zero (OECD Guidance document No. 23, OECD, 2000)). Furthermore, the high molecular molecular weight (973.62 to 11184 g/mol) and log Kow value > 10 are factors that significantly hinder the capacity of a moleculate to cross biological membranes (Guidance on information requirements and chemical safety assessment, Chapter R.11 (ECHA, 2012)).
Based on the technical difficulties associated to the performance of an algae study with Fatty acids, C18 unsaturated, trimers, 2-ethylhexyl esters, its low solubility in water and the low potential to cross biological membranes, algae testing for this substance is not deemed necessary.
References
European Chemicals Agency (ECHA, 2012). Guidance on information requirements and chemical safety assessment, Chapter R11: PBT Assessment
Organisation for Economic Co-operation and Development (2000). Guidance document on aquatic toxicity testing of difficult substances and mixtures. Environmental Health and Safety Publications, Series on Testing and Assessment No. 23., Paris, France.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
