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Registration Dossier
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EC number: 605-694-4 | CAS number: 173832-46-7
Toxicological information
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Apr - 13 May 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (adopted in 1996)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethylhexyl 8-[7,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-6-[(1E)-oct-1-en-1-yl]-1,2,5,6,7,8-hexahydronaphthalen-1-yl]octanoate; 8-[1,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-3-[(1E)-oct-1-en-1-yl]-1,2,3,4,7,8-hexahydronaphthalen-2-yl]octanoic acid; 8-[2,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-3-[(1E)-oct-1-en-1-yl]-1,2,3,4,7,8-hexahydronaphthalen-1-yl]octanoic acid; 8-[7,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-6-[(1E)-oct-1-en-1-yl]-1,2,5,6,7,8-hexahydronaphthalen-1-yl]octanoic acid
- EC Number:
- 605-694-4
- Cas Number:
- 173832-46-7
- Molecular formula:
- uvcb not available
- IUPAC Name:
- 2-ethylhexyl 8-[7,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-6-[(1E)-oct-1-en-1-yl]-1,2,5,6,7,8-hexahydronaphthalen-1-yl]octanoate; 8-[1,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-3-[(1E)-oct-1-en-1-yl]-1,2,3,4,7,8-hexahydronaphthalen-2-yl]octanoic acid; 8-[2,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-3-[(1E)-oct-1-en-1-yl]-1,2,3,4,7,8-hexahydronaphthalen-1-yl]octanoic acid; 8-[7,8-bis({8-[(2-ethylhexyl)oxy]-8-oxooctyl})-4,5-dihexyl-6-[(1E)-oct-1-en-1-yl]-1,2,5,6,7,8-hexahydronaphthalen-1-yl]octanoic acid
- Details on test material:
- - Name of test material (as cited in study report): [trade name]
- Physical state/appearance: brown liquid
- Analytical purity: no data
- Batch No.: N558331
- Densitiy: 930 kg/m³
- Storage: room temperature, in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain as cited in study report: Wistar strain Crl:(WI) BR (outbred, SPF-Quality)
- Source: Charles River, Sulzfeld, Germany
- Age at study initiation: approx. 8 weeks old
- Mean weight at study initiation: 267 g (males); 177 g (females)
- Fasting period before study: yes (overnight)
- Housing: 3 per cage in polycarbonate cages
- Diet: standard pelleted laboratory animal diet (Carfil Quality BVBA, Out-Turnhout, Belgium); ad libitum
- Water: tap water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21
- Humidity (%): 50
- Air changes (per hr): approx. 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Animals were fasted overnight prior to dosing until approx. 3-4 hours after administration of the test substance.
- Doses:
- 2000 mg/kg bw (2.15 mL/kg bw)
(Dose volume calculated as follows: dose level (g/kg) : densitiy (0.93 g/mL)) - No. of animals per sex per dose:
- - Group 1: 3 males
- Group 2: 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations: daily
- Frequency of weighing: day 1 (pre-administration), day 8 and day 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 experimental
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 cut-off according to OECD 423
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No clinical signs were observed during the study period.
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
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