Registration Dossier
Registration Dossier
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EC number: 236-828-6 | CAS number: 13501-76-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.
In a key skin sensitisation study (Buehler test) conducted according to OECD TG 406 and GLP, showed that (3-chloropropyl)diethoxymethylsilane was not sensitising to the skin of guinea pigs. There were no positive skin responses in 20/20 test group animals following challenge with 100 % test substance. No local or systemic effects were observed in this study (Hüls AG, 1997e).
Migrated from Short description of key information:
Buehler test according to OECD TG 406: not sensitising
Justification for selection of skin sensitisation endpoint:
The key study was selected for assessment.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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