Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.

In a key skin sensitisation study (Buehler test) conducted according to OECD TG 406 and GLP, showed that (3-chloropropyl)diethoxymethylsilane was not sensitising to the skin of guinea pigs. There were no positive skin responses in 20/20 test group animals following challenge with 100 % test substance. No local or systemic effects were observed in this study (Hüls AG, 1997e).

Migrated from Short description of key information:
Buehler test according to OECD TG 406: not sensitising

Justification for selection of skin sensitisation endpoint:
The key study was selected for assessment.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on skin sensitisation of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.